Protease activity of Der p 1*1Cysteine, serine or both?

Sehgal, N.; Ainsworth, Stuart; Dafforn, Timothy R.; Custovic, A.; Woodcock, Ailidh

doi:10.1016/j.jaci.2004.01.716

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Proteases That Activate Pars1

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2004

2024

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“…13,101 The proteolytic activity of Der p 1 is inhibited by specific inhibitors of both serine and cysteine proteases. 102 Their stimulation of epithelial cells to produce IL-6 and IL-8 appears to be at least in part the result of activation of PAR-2. 14 Other investigators have reported that its production of IL-8 in epithelial cells results from activation of the extracellular signal regulated kinase 1/2, mitogen-activated protein kinase, and activating peptide 1 through activation of some other receptor, but not PAR-2.…”

Section: Proteases That Activate Parsmentioning

confidence: 99%

The role of protease activation of inflammation in allergic respiratory diseases

Reed

Kita

2004

Journal of Allergy and Clinical Immunology

341

302

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Section: Proteases That Activate Parsmentioning

confidence: 99%

The role of protease activation of inflammation in allergic respiratory diseases

Reed

Kita

2004

Journal of Allergy and Clinical Immunology

341

302

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Natural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies

Gutiérrez-Vera,

García-Betancourt,

Palacios

et al. 2024

Front. Immunol.

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Allergic asthma has emerged as a prevalent allergic disease worldwide, affecting most prominently both young individuals and lower-income populations in developing and developed countries. To devise effective and curative immunotherapy, it is crucial to comprehend the intricate nature of this condition, characterized by an immune response imbalance that favors a proinflammatory profile orchestrated by diverse subsets of immune cells. Although the involvement of Natural Killer T (NKT) cells in asthma pathology is frequently implied, their specific contributions to disease onset and progression remain incompletely understood. Given their remarkable ability to modulate the immune response through the rapid secretion of various cytokines, NKT cells represent a promising target for the development of effective immunotherapy against allergic asthma. This review provides a comprehensive summary of the current understanding of NKT cells in the context of allergic asthma, along with novel therapeutic approaches that leverage the functional response of these cells.

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Protease activity of Der p 1*1Cysteine, serine or both?

Cited by 2 publications

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The role of protease activation of inflammation in allergic respiratory diseases

The role of protease activation of inflammation in allergic respiratory diseases

Natural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies

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