2023
DOI: 10.1007/s00018-023-04904-7
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Protease-independent control of parthanatos by HtrA2/Omi

Jonas Weiß,
Michelle Heib,
Thiemo Korn
et al.

Abstract: HtrA2/Omi is a mitochondrial serine protease with ascribed pro-apoptotic as well as pro-necroptotic functions. Here, we establish that HtrA2/Omi also controls parthanatos, a third modality of regulated cell death. Deletion of HtrA2/Omi protects cells from parthanatos while reconstitution with the protease restores the parthanatic death response. The effects of HtrA2/Omi on parthanatos are specific and cannot be recapitulated by manipulating other mitochondrial proteases such as PARL, LONP1 or PMPCA. HtrA2/Omi … Show more

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