Protease Inhibitors in Plasma of Patients With Chronic Urticaria

Doeglas, H.M.G.

doi:10.1001/archderm.1975.01630200039001

Cited by 37 publications

(12 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent work with polyphloretin phosphate, a prostaglandin antagonist, indicate a different effect on the reactions to prostaglandins, thurfyl nicotinate and kallikrein in patients with chronic urticaria versus normal persons [4], A precipitation via prostaglandins or prostaglandin-like mediators also seems likely because of the known effects on these substances exerted by antiphlogistica. Deficiencies of plasma protease inhibitors might play a role as suggested by D oeglas and Bleum in k [3].…”

Section: Discussionmentioning

confidence: 93%

Provocation Tests with Antiphlogistica and Food Additives in Recurrent Urticaria

Thune

A²

1975

Dermatology

View full text Add to dashboard Cite

100 patients (53 women, 47 men) suffering from recurrent urticaria were tested with different food additives such as 8 dye additives, 7 preservatives and 7 antiphlogistica. In total did 62 patients react with urticaria and/or angio-oedema. 39 patients had reactions to two or more substances while 23 patients reacted to only one substance. Reactions were induced most frequently by aspirin (27/80), dextropropoxyphene (11/45) and the azo dyes tartrazin (20/96) and sunset yellow (13/86). Asthmatic symptoms occurred in 3 and purpura in 2 patients. 13 patients out of 100 reported of immediate reactions to different foods.

show abstract

Section: Discussionmentioning

confidence: 93%

Provocation Tests with Antiphlogistica and Food Additives in Recurrent Urticaria

Thune

A²

1975

Dermatology

View full text Add to dashboard Cite

show abstract

“…Trypsin-like protease is released in cold urticarial reactions (FRAKI et al 1983). In cold urticaria, acanti-trypsin (DOEGLAS andBLEUMINK 1975) andanti-chymotrypsin (EFTEKHARI et al 1980) are reduced. In cold urticaria, acanti-trypsin (DOEGLAS andBLEUMINK 1975) andanti-chymotrypsin (EFTEKHARI et al 1980) are reduced.…”

Section: H Proteasesmentioning

confidence: 99%

Pharmacology of the Skin II

1989

Handbook of Experimental Pharmacology

View full text Add to dashboard Cite

PrefaceThe recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology.We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.It was because of this burgeoning interest in pharmacology of skin and its diseases, that this book came about. Indeed it is long overdue and was planned several years ago; we console ourselves with the thought that the delay may have served to help define certain principles which were then only just emerging.The book is divided into two volumes which are independent but complementary; the first being an account of the general pharmacology of skin, the second volume being more concerned with disease and drugs. The first volume is divided into two parts, the one dealing with the pharmacology of skin systems and their control and the other with autocoids in normal and inflamed skin. This second volume has three parts; the first part deals with the methods of measurement which are becoming of increasing importance both in studying the pharmacological effects of drugs and the clinical pharmacology of skin; the second deals with toxicology in its widest sense -including metabolism and percutaneous absorption; and the third is an account both of specific drugs and the drugs used for specific diseases.

show abstract

“…This is an example of cross-sensitization frequently found in contact Traces of metals, such as chromium, nickel and cobalt, dissolved by cooking acid or salty food in stainless-steel, may cause dermatitis. Adverse reactions following the ingestion of flavours (menthol, salicylates), butylated-hydroxyanisole and butylated-hydroxytoluene, cyclamates, saccharin and the azo dye, tartrazine, are probably not allergenic (Feingold, 1968;Lockey, 1971;Fisherman & Cohen, 1973;Miller et al 1974;Doeglas, 1975).…”

Section: Symposium Proceedings I983mentioning

confidence: 99%

Immunological aspects of food allergy

Bleumink

1983

Proc. Nutr. Soc.

View full text Add to dashboard Cite

Protease Inhibitors in Plasma of Patients With Chronic Urticaria

Cited by 37 publications

References 19 publications

Provocation Tests with Antiphlogistica and Food Additives in Recurrent Urticaria

Provocation Tests with Antiphlogistica and Food Additives in Recurrent Urticaria

Pharmacology of the Skin II

Immunological aspects of food allergy

Contact Info

Product

Resources

About