2021
DOI: 10.1080/09553002.2021.1962567
|View full text |Cite
|
Sign up to set email alerts
|

Proteases, protease inhibitors and radiation carcinogenesis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
3
0

Year Published

2022
2022
2025
2025

Publication Types

Select...
3
1

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(3 citation statements)
references
References 86 publications
0
3
0
Order By: Relevance
“…Several vitamin approaches mentioned above are covered in detail in another paper in this issue (Singh et al). Dietary supplementation with Bowman-Birk protease inhibitors derived from soybeans ( Shaghagi et al, 2021 ; Kennedy, 2021 ), L-selenomethionine, or a combination of selected antioxidant agents ( Guan et al, 2004 ; Kennedy et al, 2007 ) has shown promise to prevent the decrease in antioxidants in the plasma of mice exposed to proton or HZE particle radiation. Adding nutritional foods, such as blueberries, to crew diets may provide added benefits to help reduce ROS and mitigate radiation-induced CNS effects, as reported in animal studies using space-relevant radiation exposures ( Poulose et al, 2017 ).…”
Section: Overlapping Mechanisms Of Radiation Injury Drug Classes With...mentioning
confidence: 99%
“…Several vitamin approaches mentioned above are covered in detail in another paper in this issue (Singh et al). Dietary supplementation with Bowman-Birk protease inhibitors derived from soybeans ( Shaghagi et al, 2021 ; Kennedy, 2021 ), L-selenomethionine, or a combination of selected antioxidant agents ( Guan et al, 2004 ; Kennedy et al, 2007 ) has shown promise to prevent the decrease in antioxidants in the plasma of mice exposed to proton or HZE particle radiation. Adding nutritional foods, such as blueberries, to crew diets may provide added benefits to help reduce ROS and mitigate radiation-induced CNS effects, as reported in animal studies using space-relevant radiation exposures ( Poulose et al, 2017 ).…”
Section: Overlapping Mechanisms Of Radiation Injury Drug Classes With...mentioning
confidence: 99%
“…PIs with antineoplastic action have no discernible effect on normal cells, but they are capable of negating carcinogen-induced cellular changes in different studies ( 35 , 36 ). The inhibitory profiles of PIs that affect transformation have been examined since not all PIs have the ability to prevent the transformation in vivo ( 37 , 38 ). For instance, chymostatin - a very common and efficient chymotrypsin inhibitor is one of the most effective PI that suppresses the transformation.…”
Section: Introductionmentioning
confidence: 99%
“…For instance, chymostatin - a very common and efficient chymotrypsin inhibitor is one of the most effective PI that suppresses the transformation. It has the ability to eliminate radiation–induced transformation in vitro with only picomolar concentrations in the medium ( 38 ). BBI family inhibitors are effective in suppressing transformation with nanomolar concentrations ( 39 ).…”
Section: Introductionmentioning
confidence: 99%