Proteasome inhibitor bortezomib prevents proliferation and migration of pulmonary arterial smooth muscle cells
Yi‐Ching Liu,
Yu‐Hsin Tseng,
Yu‐Hsin Kuan
et al.
Abstract:Pulmonary vascular remodeling is a key pathological process of pulmonary arterial hypertension (PAH), characterized by uncontrolled proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). Bortezomib (BTZ) is the first Food and Drug Administration (FDA)‐approved proteasome inhibitor for multiple myeloma treatment. Recently, there is emerging evidence showing its effect on reversing PAH, although its mechanisms are not well understood. In this study, anti‐proliferative and anti‐migratory … Show more
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