Wildlife preservation and protection is a necessary condition for the implementation of sustainable development. It is a determining factor in the possibility of continued human existence as a species at the present stage of biosphere development. The reduction of natural ecosystems’ territories, and, as a result of this, the reduction of their biodiversity, negatively affects the quality of life of different regions and of humanity as a whole. One of the ways to optimize the environment, preserve natural ecosystems and improve the quality of human environment is creation of ecological frameworks of the regions. Shipov Forest, Tellerman Forest, Khopersky Reserve, Voronezh State Nature Reserve named after V.M. Peskov, a forest-green zone of the city of Voronezh (currently under construction) will be the main centers of the ecological framework of the Voronezh region. At the same time, there are 244 specially protected natural territories of regional and local subordination in the Voronezh region. They belong to different areas of protected territories, categories and profiles. When creating an ecological framework, these territories are included into ecological framework, thereby expanding its territory and strengthen its environment-forming functions.