Global food production faces great challenges in the future. With a future world population of 9.6 billion by 2050, rising urbanization, decreasing arable land, and weather extremes due to climate change, global agriculture is under pressure. While today over 50 % of the world population live in cities, by 2030, the number will rise to 70 %. In addition, global emissions have to be kept in mind. Currently, agriculture accounts for around 20-30 % of global greenhouse gas emissions. Shifting food production to locations with high demands reduces emissions and mitigates climate change. Urban horticulture increases global food production by exploiting new locations for cultivation. However, higher land prices and urban pollution constrain urban horticulture. In this paper, we review different urban cultivation systems throughout the world. Our main findings from ecological, economical, and social aspects are: (1) Urban horticulture activities are increasing globally with at least 100 million people involved worldwide. With potential yields of up to 50 kg per m 2 per year and more, vegetable production is the most significant component of urban food production which contributes to global food security. (2) Organoponic and other low-input systems will continue to play an important role for a sustainable and secure food production in the future. (3) Despite the resource efficiency of indoor farming systems, they are still very expensive. (4) Integrating urban horticulture into educational and social programs improves nutrition and food security. Overlaying these, new technologies in horticultural research need to be adopted for urban horticulture to increase future efficiency and productivity. To enhance sustainability, urban horticulture has to be integrated into the urban planning process and supported through policies. However, future food production should not be "local at any price," but rather committed to increase sustainability.