Protectin DX ameliorates sepsis-induced acute lung injury by suppressing neutrophil activation via inhibition of the MAPK/NF-κB /p47phox-ser345 signaling pathway
Abstract:Background Sepsis-induced acute lung injury (ALI) is one of the leading causes of death among critically ill patients. It is reported that Protectin DX (PDX), a kind of special pro-resolving mediator (SPM), has been recently discovered to contribute to the improvement of inflammatory diseases. However, its effect and mechanism on regulating ALI are still unknown.
Methods We used C57BL/6J mice to construct ALI model via cecal ligation and puncture (CLP). Mice were injected intraperitoneally with saline or PDX o… Show more
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