Protecting Effect of Chitin and Chitosan on Experimentally Induced Murine Candidiasis

Suzuki, Ko; Okawa, Yoshio; Hashimoto, Kazuhiko; Suzuki, Shigeo; Suzuki, Masuko

doi:10.1111/j.1348-0421.1984.tb00746.x

Cited by 101 publications

(50 citation statements)

References 27 publications

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“…Furthermore, the number of PMN increased significantly in both types of tumor-bearing mice. It is well known that active oxygen intermediates are important candidacidal factors (12). Our results showed that the contents of PMN active oxygens increased in ascites tumor-bearing mice compared to in normal control mice.…”

Section: Notessupporting

confidence: 60%

Augmentation of Host Resistance to Candida albicans Infection in Ascites Tumor‐Bearing Mice

Okawa

Murata

Kobayashi

et al. 1992

Microbiology and Immunology

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We found that the number of peripheral blood polymorphonuclear leukocytes (PMN) dramatically increased in both sarcoma 180 (S-180) and MM-46 mammary carcinoma (MM-46) ascites tumor-bearing mice, and mice required a remarkable resistance to Candida albicans infection via intravenous route. When the resistance was determined by number of cells of C. albicans in the kidney, a significant decrease in the number of fungal cells was observed in the kidneys of infected ascites tumor-bearing mice. An increase of active oxygen levels of PMN from ascites tumorbearing mice was observed, suggesting that this factor is important in developing of resistance in ascites tumor-bearing mice. Additionally, a cultur e supernatant of tumor cells co-cultivated with bone-marrow cells in vitro increased the number of granulocytes and macrophages differentiated from the bone-marrow cells.

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Section: Notessupporting

confidence: 60%

Augmentation of Host Resistance to Candida albicans Infection in Ascites Tumor‐Bearing Mice

Okawa

Murata

Kobayashi

et al. 1992

Microbiology and Immunology

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“…Rementería et al (233) extended the earlier studies to examine chitin purified from the C. albicans cell wall. They reported that, as observed by Suzuki et al (279), injection of mice with purified C. albicans chitin (30 mg kg Ϫ1 ) increased the survival time in response to a C. albicans challenge of 10 5 cells. In these experiments, it was explicitly stated that control mice were given an injection of saline to control for the stress of the injection itself.…”

Section: Immune Cell Receptors and Interactionsmentioning

confidence: 60%

“…Suzuki et al (279) first reported the immunological effects of chitin in a murine model of candidiasis. Mice receiving pretreatment with chitin (50 mg kg Ϫ1 ) were better able to survive a lethal challenge with C. albicans than were mice receiving no treatment.…”

Section: Immune Cell Receptors and Interactionsmentioning

confidence: 99%

Surface Glycans ofCandida albicansand Other Pathogenic Fungi: Physiological Roles, Clinical Uses, and Experimental Challenges

2004

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Although fungi have always been with us as commensals and pathogens, fungal infections have been increasing in frequency over the past few decades. There is a growing body of literature describing the involvement of carbohydrate groups in various aspects of fungal disease. Carbohydrates comprising the cell wall or capsule, or as a component of glycoproteins, are the fungal cell surface entities most likely to be exposed to the surrounding environment. Thus, the fungus-host interaction is likely to involve carbohydrates before DNA, RNA, or even protein. The interaction between fungal and host cells is also complex, and early studies using whole cells or crude cell fractions often produced seemingly conflicting results. What was needed, and what has been developing, is the ability to identify specific glycan structures and determine how they interact with immune system components. Carbohydrate analysis is complicated by the complexity of glycan structures and by the challenges of separating and detecting carbohydrates experimentally. Advances in carbohydrate chemistry have enabled us to move from the foundation of composition analysis to more rapid characterization of specific structures. This, in turn, will lead to a greater understanding of how fungi coexist with their hosts as commensals or exist in conflict as pathogens

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“…It shows similarity in the basic molecular structure of hyaluronic acid and is distinguished by its biological properties such as anti-bacterial action and atoxicity [12][13][14], make it an excellent agent for the prevention of postoperative adhesions. For clinical use, it is essential that Carboxymethyl Chitosan (CMC) be submitted to a sterilization process.…”

Section: Introductionmentioning

confidence: 99%

Prevenção de aderências pericárdicas pós-operatórias com uso de carboximetilquitosana termoestéril

Daroz¹,

Lopes²,

Dallan³

et al. 2008

Rev Bras Cir Cardiovasc

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Objective: The aim of this study is to evaluate CMC physicalchemical alterations after thermal sterilization and its efficacy in preventing poststernotomy pericardial adhesions.Methods: After autoclaving thermal sterilization, thermal sterile Carboxymethyl Chitosan (CMCts) was submitted to physical-chemical analysis. Twelve animals were divided into two groups and underwent pericardiotomy and adhesion induction protocol. Afterward, topic CMCts or saline solution was administered. After 8 weeks, a sternotomy was performed for adhesion score macroscopic evaluation, dissection time and the amount of recalcitrant dissection, and microscopic evaluation.Results: Physical-chemical analysis showed no difference between CMC and CMCts. A macroscopic analysis showed that the intensity of adhesions was significantly lower in the CMCts group (P=0.007). Dissection time and use of recalcitrant dissection also decreased significantly (P=0.007, P=0.008; respectively). Microscopic results indicated a significant reduction in the epicardium collagen area and in the total epicardium area (P=0.05) and (P=0.03). Conclusion ResumoObjetivo: Este trabalho tem como objetivo avaliar alterações físico-químicas da carboximetilquitosana após termoesterilização e sua eficácia na prevenção de aderências pericárdicas pós-esternotomia.Métodos: Após ser submetida a termoesterilização em autoclave, a carboximetilquitosana termoestéril (CMQte) foi submetida a análises físico-químicas. Doze animais foram divididos em dois grupos e submetidos à pericardiotomia e a protocolo de indução de aderências. A seguir, foi aplicada de forma tópica a CMQte ou solução 6. Titular Professor of the Discipline

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Protecting Effect of Chitin and Chitosan on Experimentally Induced Murine Candidiasis

Cited by 101 publications

References 27 publications

Augmentation of Host Resistance to Candida albicans Infection in Ascites Tumor‐Bearing Mice

Augmentation of Host Resistance to Candida albicans Infection in Ascites Tumor‐Bearing Mice

Surface Glycans ofCandida albicansand Other Pathogenic Fungi: Physiological Roles, Clinical Uses, and Experimental Challenges

Prevenção de aderências pericárdicas pós-operatórias com uso de carboximetilquitosana termoestéril

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