Protecting group-free introduction of amino acids to polymers through the aza-Michael reaction

Abstract

The incorporation of natural amino acids onto a silicone framework is efficiently and simply achieved, without protecting groups or solvents, by using aza-Michael addition to acrylate-modified silicones.

Biodegradable, crosslinked silicone-gelatin hydrogels

“…The peptide/amino acid modified silicones 30 produced during elastomer biodegradation may be of interest in their own right. Silicone surfactants, which have interesting foam stabilization or defoaming characteristics in addition to the ability to act as emulsifiers, 24 utilize poly ethers as hydrophiles.…”