Protecting‐Group‐Free Synthesis of Natural Products and Analogs, Part I

Linear Tetraquinanes by Microwave Assisted [3+2] Cycloaddition and Ring‐Rearrangement Metathesis

“…To construct these kind of skeletons, it usually requires a large number of steps and also involve usage of protection and deprotection steps. [11] Chemists around the world are working on the strategies by which these polyquinanes can be made efficiently and in lesser number of steps. Since the metathesis is known to be useful to design complex molecules, we are interested in exploring newer tactics to construct various complex structures by utilizing ring-rearrangement metathesis (RRM).…”

“…To construct these kind of skeletons, it usually requires a large number of steps and also involve usage of protection and deprotection steps [11] . Chemists around the world are working on the strategies by which these polyquinanes can be made efficiently and in lesser number of steps.…”

Conversion of Alkyl Azides to Diazo Compounds and the Azide-Site Selectivity: One-Pot Phosphine-Mediated Transient Protection of Azido Groups and Deprotective Transformation to Diazo Groups

“…Nevertheless, the protection of functional groups remains important because it is not always possible to achieve an ideal direct (site-)selective transformation or a protecting group-free synthesis. 7,8 Therefore, the development of a deprotection step is worthwhile to improve the efficiency and to contribute to the synthetic progress. For this purpose, deprotective conversion of the protected groups could increase the synthetic efficiency by direct conversion into different functionalities or further contribution to skeletal construction in one step (Scheme 1b).…”