Personal data security is a cybersecurity trend that has captured the world’s attention. Governments, practitioners and academics are jointly building personal data security in various communication systems, including IoT. The protocol that is widely used in IoT implementation is MQTT. By default, MQTT does not provide data security features in the form of data encryption. Therefore, this research was carried out on the design of Secure End-to-End Encryption MQTT with Block Cipher-Based Lightweight Cryptography. The protocol is designed by utilizing the Galantucci secret sharing scheme and a lightweight cryptographic algorithm based on a block cipher. The algorithms used include AES-128 GCM mode, GIFT-COFB, Romulus N1, and Tiny JAMBU. We tested the Secure End-to-End for MQTT protocol on the ARM M4 and ESP8266 processors. Our testing results on NodeMCU board, Tiny JAMBU have an average encryption time of 313 and an average decryption time of 327 . AES-128 GCM mode has an average encryption time of 572 and an average decryption time of 584 . GIFT-COFB has an average encryption time of 1094 and an average decryption time of 1110 . Meanwhile, Romulus N1 has an average encryption time of 2157 and an average decryption time of 2180 . On STM32L4 discovery, Tiny JAMBU had average encryption of 82 and an average decryption time of 85 . AES-128 GCM mode has an average encryption time of 163 and an average decryption time of 164 . GIFT-COFB has an average encryption time of 164 and an average decryption time of 165 . Meanwhile, Romulus N1 has an average encryption time of 605 and an average decryption time of 607 . Our experiment shows that the fastest performance is produced by Tiny JAMBU, followed by AES-128 Mode GCM, GIFT-COFB and Romulus N1.