Protecting newborns from pertussis: The role of partner vaccination in the era of maternal immunization

Krishnaswamy, Sushena; Wallace, Euan M.; Cheng, Allen; Buttery, Jim; Giles, Michelle

doi:10.1016/j.ejogrb.2017.07.031

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…Uptake of pertussis vaccine was higher with 82.9% of pregnant women receiving the vaccine. This is higher than other recent Victorian studies demonstrating uptakes of 64 and 70% 13,22 …”

Section: Discussioncontrasting

confidence: 67%

Antenatal vaccine uptake: A cross‐sectional study investigating factors influencing women’s choices in pregnancy

Moir

Gunter

Lynch

et al. 2020

Aust NZ J Obst Gynaeco

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Background: Seasonal influenza and pertussis cause significant morbidity and mortality among expectant mothers and infants. Vaccination during the antenatal period is an important public health intervention, minimising rates of maternal, neonatal and infant infection. Aims: The primary aim of this project was to establish the rates of antenatal vaccine uptake. Secondly, the study aimed to determine socio-demographic factors significant to vaccine uptake. Thirdly, the project aimed to produce a thematic analysis of the factors affecting vaccination uptake during pregnancy. Materials and Methods: A cross-sectional observational study was conducted among women attending a large maternity hospital, in the western suburbs of Melbourne, for perinatal care. Data were collected via self-completed questionnaires after delivery. Data from the questionnaires were entered into an electronic database, and STATA was used to undertake correlation analysis. Results: Over a 12-month period 1678 women completed questionnaires and 1305 were eligible for further analysis. The uptake of influenza vaccine was 48.3%, pertussis vaccine uptake was higher, at 82.9%. Uptake of influenza and pertussis vaccines strongly correlated with recommendations from healthcare providers (odds ratios 29.7 and 63.8 respectively). Maternal country of birth, age and parity were significant predictors of vaccine uptake. In thematic analysis, healthcare provider recommendation and the perceived risk of the disease were factors resulting in vaccination. Conclusion: This study determined the rate of antenatal vaccine uptake and significant socio-demographic determinants affecting uptake at a large maternity hospital in metropolitan Melbourne. Ensuring healthcare providers recommend vaccination is likely to improve coverage.

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“…Uptake of pertussis vaccine was higher with 82.9% of pregnant women receiving the vaccine. This is higher than other recent Victorian studies demonstrating uptakes of 64 and 70% 13,22 …”

Section: Discussioncontrasting

confidence: 67%

Antenatal vaccine uptake: A cross‐sectional study investigating factors influencing women’s choices in pregnancy

Moir

Gunter

Lynch

et al. 2020

Aust NZ J Obst Gynaeco

View full text Add to dashboard Cite

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“…Our findings recognized adults as the reservoirs of infection for pertussis for transmission to vulnerable infants, the new vaccination strategies in adults, such as the "cocooning strategy" and maternal immunization during the last trimester of pregnancy, or universal immunization may be considered [18,26,27,28].…”

Section: Discussionmentioning

confidence: 79%

Seroprevalence of pertussis in adult population

2018

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Introduction/Objective Seroepidemiological studies are crucial for better understanding of pertussis epidemiology. The aim of this study was to assess the seroprevalence of anti-Bordetella pertussis toxin antibodies (anti-PT IgG) in the adult population of Novi Sad, and to evaluate the differences by age and sex. Methods A cross-sectional study was conducted in 468 healthy adults aged ≥ 20 years stratified into seven age groups. The youngest of our participants received the last dose of the vaccine at least 18 years ago. Positive results of anti-PT IgG concentrations were considered a consequence of natural pertussis infection or reinfection. A commercial ELISA kit (Euroimmun®, Lübeck, Germany), with anti-PT IgG with four calibrators (5 IU/mL, 25 IU/mL, 100 IU/mL, and 200 IU/mL) was used. Results Most of the subjects (53.8%) had anti-PT IgG of > 5 to < 62.5 IU/mL. The proportion of participants with high concentrations (62.5 to < 125 IU/mL) was statistically significantly higher in females than in males (5.4% vs. 0.4%, p = 0.002). The highest values of anti-PT IgG were detected among subjects in the age group of 20-24 years (17.5 ± 22.2 IU/mL), and in the participants ≥ 60 years of age (15.0 ± 29.4 IU/ mL). The percentage of anti-PT IgG concentration of ≥ 62.5 IU/mL was the highest among subjects aged ≥ 60 years (6.6%) and among those aged 20-24 years (5%). Conclusions The limited duration of vaccine-induced immunity with subsequent infection or reinfection enables the circulation of pertussis in the adult population of Novi Sad that serves as the reservoir of infection for transmission to vulnerable persons.

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“…11 (1) 173 (20) 69 ( 8 (18) 154 (18) 106 (12) 448 ( 52) 63 (15) 93 (23) 58 (14) 195 (48) 48 (38) 16 (13) 14 (11) 49 ( 39 # Other included a variety of responses including providers reporting a combination of the three main provider groups, and comments such as "whoever is the primary provider" and "whoever sees her at the booking visit"…”

Section: Discussionmentioning

confidence: 99%

“…For example, reported rates for pertussis vary from 14-64% in the US 7,8 , 30-60% in the UK, [9][10][11] and 27-70% in Australia. [12][13] Barriers to uptake can be categorised as consumer-, healthcare provider-or system-related. Examples of these barriers include lack of consumer and healthcare provider (HCP) awareness of recommendations, consumer and HCP concerns about vaccine safety and efficacy during pregnancy, lack of HCP recommendation, access to vaccines, failure to incorporate vaccination into routine pregnancy care, and, in some jurisdictions, cost.…”

Section: Author Manuscriptmentioning

confidence: 99%

A study comparing the practice of Australian maternity care providers in relation to maternal immunisation

Krishnaswamy

Wallace

Buttery

et al. 2018

Aust NZ J Obst Gynaeco

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Protecting newborns from pertussis: The role of partner vaccination in the era of maternal immunization

Cited by 8 publications

References 24 publications

Antenatal vaccine uptake: A cross‐sectional study investigating factors influencing women’s choices in pregnancy

Antenatal vaccine uptake: A cross‐sectional study investigating factors influencing women’s choices in pregnancy

Seroprevalence of pertussis in adult population

A study comparing the practice of Australian maternity care providers in relation to maternal immunisation

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