There are increased mental health and well-being concerns among students at universities worldwide. By adopting a conceptual review of literature, this chapter analyzed well-being and mental health initiatives for students in universities. On the bases of the literature review in this chapter, it is concluded that there is need for supportive work environments, mental health in universal health coverage, creating opportunities for student engagement, mentorship at various academic departments building social networks, and finally, individual coping strategies are also useful in enhancing well-being and mental health of academic staff at universities. It is recommended that universities should develop holistic mentorship for students so that this can take care of all aspects of their lives.