Protecting the Ocular Surface and Improving the Quality of Life of Dry Eye Patients: A Study of the Efficacy of an HP-Guar Containing Ocular Lubricant in a Population of Dry Eye Patients

Abstract

The improvements in ocular surface staining and dry eye symptoms with the HPG containing ocular lubricant -- evident as early as the first follow-up visit (Day 7) and continued throughout the 28 days of the study with a concurrent, increase in OPI to a level greater than unity -- indicate that this preparation is a fast-acting, long-lasting, and effective treatment for dry eye. In concurrence with the results from previously published clinical studies, the HPG containing ocular lubricant has shown efficacy in alleviating the signs and symptoms of dry eye as well as affording improved ocular surface protection.

Effect of Loteprednol Etabonate 0.5% on Initiation of Dry Eye Treatment With Topical Cyclosporine 0.05%

“…16,18 A number of AT preparations claim to enhance tear film stability, decrease evaporative tear loss, or confer osmoprotective effects. [18][19][20][21] Cyclosporine A (CsA) is an established systemic immunosuppressive agent, approved in topical (tCsA) emulsion formulation (Restasis, Allergan, Irvine, CA) for topical therapy of KCS and recommended for the treatment of moderate-tosevere inflammation, level 2 or higher, associated with DES. 16 On the ocular surface, tCsA acts as an immunomodulator, downregulating T-cell activity without any documentation of increased infection risk or immunosuppression.…”

Hipertensão ocular "mascarada" por edema de córnea após cirurgia da catarata

“…O tratamento com suplementação alimentar a base de ácidos graxos insaturados essenciais tipo ômega 3 tem se mostrado eficaz em diversos estudos (41)(42)(43) . O uso de colírio lubrificante a base de HP Guar é indicado no tratamento de disfunção lacrimal, principalmente se estiver relacionado com ceratopatia ponteada, bem como alterações da camada mucóide do filme lacrimal (44)(45) . Relatamos um caso de hipertensão ocular associado à edema de córnea após cirurgia de catarata em que a medida da pressão ocular por meio de TAG era hipoestimado.…”

Eye

“…Unfortunately the ideal non crust forming and stability improving gelling agent has not yet been developed. It seems that hydroxypropyl-guar possess more specific adhesive properties to injured ocular surfaces [35][36][37].…”

“…Apart from the polymers mentioned in Table 10.6 some authorised medicines contain other viscosity enhancing agents such as dextran, hydroxyethylcellulose, hyaluronic acid and hydroxypropylguar gum (HP-guar; Systane®) [36,37,57]. Hyaluronic acid possesses good adhesive properties.…”