Protection against dental caries in rats by glycerophosphates or calcium salts or mixtures of both

Grenby, T.H.; Bull, J M

doi:10.1016/0003-9969(75)90041-2

Cited by 14 publications

(11 citation statements)

References 8 publications

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“…As trials have shown that calcium glycerophosphate is strongly caries inhibito ry in animals [for references see Grenby, 1973 andBull, 1975], the ini tial trials were carried out with this agent. The calcium glycerophosphate was either applied topically to the enamel surface as a saturated solution or added to the acid buff er solution at the third demineralization at a concentration of l°/o.…”

Section: Resultsmentioning

confidence: 99%

“…Among the strongest contend ers are certain phosphate-containing com pounds. Their properties and anticaries ac tivity have formed the subject of a sympo sium containing 17 papers [Coates et al, 1964], Several have proven anticaries effec tiveness in laboratory animals, including di sodium hydrogen phosphate and calcium dihydrogen phosphate [for a summary of trials see Nizel and Harris, 1964], sodium trimetaphosphate [Navia et al, 1968] and calcium glycerophosphate [Grenby and Bull, 1975], Other phosphate-containing compounds which have been put forward as caries-inhibiting agents, but which have not shown such consistent effectiveness in labo ratory trials, include phytates and calcium sucrose phosphate [for a summary of refer ences see Grenby, 1973], Much less data are available on the effectiveness of this whole range of com pounds in man. There is also a shortage of information about their mechanisms of ac tion and the optimum routes and levels of application.…”

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confidence: 99%

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Chemical Studies of the Protective Action of Phosphate Compounds against the Demineralization of Human Dental Enamel in vitro

Grenby¹,

Bull²

1980

Caries Res

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Demineralization of enamel by acid buffer and the use of protective agents to combat it were studied by two different techniques, one using intact enamel surfaces and the other powdered enamel. Compared with the acknowledged protective effect of fluoride, calcium glycerophosphate was the most effective phosphate compound. Sodium phytate and calcium sucrose phosphate gave less consistent results. Applied topically, α-glycerophosphate was more effective than β-glycerophosphate. Pretreating the enamel with saliva or a protein solution improved its resistance to the attack of acid buffer but reduced the apparent effectiveness of the protective agents.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Chemical Studies of the Protective Action of Phosphate Compounds against the Demineralization of Human Dental Enamel in vitro

Grenby¹,

Bull²

1980

Caries Res

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“…The mechanism for this observation is unclear. Grenby (1990) investigated the cariogenic potential in rats of a variety of starchy foods. A sucrose control group developed the most caries followed by a rich tea biscuit group, then a potato crisps group.…”

Section: E N T a L C A R I E S -T H E R O L E O F D I E T A R Y S Tmentioning

confidence: 99%

“…Bulk non-sugar sweeteners (sorbitol, mannitol, lactitol, isomalt and lycasin) are chemically related to sugars and are very slowly metabolized by the oral bacteria. However, extensive research has shown that they are non-cariogenic or virtually so (see Grenby, 1991). Xylitol is not metabolized and is a salivary stimulant; however, the possibility of an anti-S. mutans effect of xylitol has yet to be clearly quantified (Bar, 1988).…”

Section: N O N -S U G a R S W E E T E N E R Smentioning

confidence: 99%

The Relationship Between Diet, Nutrition and Dental Health: an Overview and Update for the 90s

Moynihan

1995

Nutr. Res. Rev.

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“…In principle, the chemical properties of this interface can be altered to decrease the cariogenic challenge originating from the metabolism of the oral flora. Several agents have been advanced as constituents of mouthwashes to minimize enamel demineralization, for example, lactate dehydrogenase [Higham and Edgar, 1991], urea and fluoride [Pearce, 1982[Pearce, , 1984Pearce and Nelson, 1988;Pearce et al, 1991], calcium phosphate [Stralfors, 1964;Rankine et al, 1989], calcium lactate [van der Hoeven, 1985;Shrestha et al, 1982;van der Hoeven et al, 1989;Kashket and Yaskell, 1992], calcium glycerophosphate [Bowen, 1972;Grenby and Bull, 1975;Sidi and Wilson, 1991] …”

mentioning

confidence: 99%

Comparative Reduction of Enamel Demineralization by Calcium and Phosphate in vitro

Tanaka¹,

Kadoma

2000

Caries Res

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In theory, calcium and phosphate in the plaque fluid exert a large influence on the demineralization of enamel surface. In order to know the effect of increasing the concentration of either of these factors, the following in vitro experiment was conducted. Three thin sections, about 150 Ìm thick, were cut out from each of 13 human premolars. All surfaces of the sections, except for the original enamel surface, were coated with nail varnish. These sections were immersed into one of two sets of demineralizing solutions for 1 week at 25°C. Each set, the ‘calcium set’ and the ‘phosphate set’, contained three solutions. The composition of these solutions differed mainly in calcium or phosphate concentrations. After 1 week, the degree of demineralization was determined by image analysis of contact microradiograms from each section. The subsurface demineralization in enamel was reduced by 95% by increasing the calcium concentration of the demineralizing solution from 7 to 21 mmol/l. A similar reduction (87%) was observed by increasing the phosphate concentration. However, the amount of phosphate needed was approximately 20 times more than that of calcium. The larger inhibitory effect that calcium has on enamel demineralization was related to the larger effect it has on the degree of saturation of the solution. Even though no statistically significant difference was found between the effect of calcium and phosphate on the demineralization of enamel (when the solutions had the same degree of saturation), the difference in the standard deviation of demineralization suggests the existence of some other factors which have an influence on the demineralization reaction.

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Protection against dental caries in rats by glycerophosphates or calcium salts or mixtures of both

Cited by 14 publications

References 8 publications

Chemical Studies of the Protective Action of Phosphate Compounds against the Demineralization of Human Dental Enamel in vitro

Chemical Studies of the Protective Action of Phosphate Compounds against the Demineralization of Human Dental Enamel in vitro

The Relationship Between Diet, Nutrition and Dental Health: an Overview and Update for the 90s

Comparative Reduction of Enamel Demineralization by Calcium and Phosphate in vitro

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