1982
DOI: 10.1038/298030a0
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Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

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Cited by 772 publications
(330 citation statements)
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“…First, the FMDV structures determined by Stuart and colleagues (16)(17)(18)(19) revealed that, contrary to other picornaviruses, no canyon or pit was present on the smooth FMDV surface. Furthermore, the critical receptor recognition Arg-Gly-Asp domain was located on a highly mobile loop (the G-H loop of VP1), which was also a major antigenic site for the virus (20)(21)(22). Additional structural work by Fita and colleagues (23) further indicated that the ArgGly-Asp motif is not only part of the receptor recognition site but it also interacts directly with some anti-viral neutralizing antibodies.…”
mentioning
confidence: 96%
“…First, the FMDV structures determined by Stuart and colleagues (16)(17)(18)(19) revealed that, contrary to other picornaviruses, no canyon or pit was present on the smooth FMDV surface. Furthermore, the critical receptor recognition Arg-Gly-Asp domain was located on a highly mobile loop (the G-H loop of VP1), which was also a major antigenic site for the virus (20)(21)(22). Additional structural work by Fita and colleagues (23) further indicated that the ArgGly-Asp motif is not only part of the receptor recognition site but it also interacts directly with some anti-viral neutralizing antibodies.…”
mentioning
confidence: 96%
“…Antiviral responses to peptide immunogens have been extremely variable. The greatest progress has probably been achieved using peptides corresponding to the surface-exposed G-H loop of VP1 of foot-and-mouth disease virus (FMDV), which can elicit a neutralizing antibody response (Bittle et al, 1982;Pfaff et al, 1982) that is protective in target species (DiMarchi et al, 1986). Approximately 35 % of the antibodies induced by these peptides in laboratory animals also recognize virus (Parry et al, 1988) but, even so, the levels of protection attained in target species have been inconsistent.…”
Section: Introductionmentioning
confidence: 99%
“…The difference between the 2 isolates and O1K lies in the main VP1 antigenic domain on each side of the highly conserved arginine-glycine-aspartate sequence. 3 Changes in amino acid sequence in this region are most probably responsible for the subtype antigenic identity of the isolates. All the data presented here strongly suggest that the 2 events originated from the same virus subtype of the O serotype.…”
Section: Methodsmentioning
confidence: 99%
“…The virus genome is an 8.5-kilobase (kb) single strand of RNA in the plus orientation, carrying a poly A tract at its 3' end and a viral genome protein (VPg) at its 5' end. 3,6 The virion, an icosahedral capsid, consists of 60 copies of each of the four proteins, VP1-4, of which VP1 is the main protein determining antigenic identity. 1,10 The differences in VP1 sequences are the basis for developing reverse transcriptase polymerase chain reaction (RT-PCR) tests to identify different serotypes.…”
mentioning
confidence: 99%