Protection Against Homologous Disease in Hybrid Mice by Passive and Active Immunological Enhancement-Facilitation

Experimental Models for Prevention of Graft-versus-Host Reaction in Bone Marrow Transfusion

“…This enhancement has been applied to protect the F 1 recipients from the GVH reaction by the transfer of parental lymphoid cells as reported by Voisin et al [23], and Jose et al [12]. In this study, injection of host-directed antibody suppressed both splenomegaly and cytotoxicity as shown in Tables 1 and 2.…”

“…Fink et al [6] have reported that antibodyproducing cells injected together with lymphoid cells suppress local GVH reaction in rats as demonstrated by the popliteal lymph node assay. Voisin et al [23] have reported that F 1 recipients are protected from the lethal effect of GVH reaction when parental donors have been immunized with lyophilized tissue antigen of the partner strain. In this study, splenomegaly and cytotoxicity did not occur in F 1 recipients when AKR donors have been immunized with sonicated cellular antigen of C57BL/6 mice as shown in Tables 1 and 2.…”

Experimental Models for Prevention of Graft-versus-Host Reaction in Bone Marrow Transfusion

“…It may be ascribed to the induction of antibody production against C57BL/6 antigens in AKR donors and the antibody-induced sup pression of GVH reaction in FI recipients, since isoantibodies against major histocom patibility antigens can be raised readily in such a situation and the presence of anti body can suppress the induction of GVH re action [3,7,14]. Repeated pretreatments of C3H/He donors with sonicated AKR spleen cells did not suppress the generation of cy totoxic lymphocytes in the spleen of FI re cipients.…”

Suppression of the Graft-versus-Host Reaction by Passive Immunization of Donor against Recipient Antigens

“…Voisin and Kinsky (7) have reported that newborn mice are significantly protected from the cell mediated graft-versus-host reaction (GVHR) induced by injection of allogeneic spleen cells from adult donors if small amounts of antibody against recipient tissue antigens are administered simultaneously. I t has also been demonstrated that active immunization of the lymphoid cell donor against recipient tissue antigens may lower the capacity of the lymphoid cells to mount a GVHR against newborn recipients (8) and against adult hybrid recipients (9). The protection afforded the host against the GVHR was believed to operate through the same mechanism (s) by which enhancing antiserum protects a tumor against rejection and was termed immunological enhancement-facilitation (9).…”

“…I t has also been demonstrated that active immunization of the lymphoid cell donor against recipient tissue antigens may lower the capacity of the lymphoid cells to mount a GVHR against newborn recipients (8) and against adult hybrid recipients (9). The protection afforded the host against the GVHR was believed to operate through the same mechanism (s) by which enhancing antiserum protects a tumor against rejection and was termed immunological enhancement-facilitation (9). This report deals with suppression of the GVHR by passively immunizing the cell donor with antiserum directed against the host's H-2 antigens.…”