2024
DOI: 10.1101/2024.05.06.592814
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Protection againstClostridioides difficiledisease by a naturally avirulentC. difficilestrain

Qiwen Dong,
Stephen Harper,
Emma McSpadden
et al.

Abstract: Clostridioides difficile (C. difficile) strains belonging to the epidemic BI/NAP1/027 (RT027) group have been associated with increased transmissibility and disease severity. In addition to the major toxin A and toxin B virulence factors, RT027 strains also encode the CDT binary toxin. Our lab previously identified a toxigenic RT027 isolate, ST1-75, that is avirulent in mice despite densely colonizing the colon. Here, we show that co-infecting mice with the avirulent ST1-75 and virulent R20291 strains protects… Show more

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