Protection against meningococcal serogroup ACYW disease in complement-deficient individuals vaccinated with the tetravalent meningococcal capsular polysaccharide vaccine

Fijen, C. A. P.; Kuijper, Ed J.; Drogari‐Apiranthitou, Maria; Leeuwen, Yvonne van; Daha, Mohamed R.; Dankert, J.

doi:10.1046/j.1365-2249.1998.00738.x

Cited by 75 publications

(42 citation statements)

References 27 publications

(52 reference statements)

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“…In this way, it is quite conceivable that complement deficiency might delay establishment of immunity. By contrast, distinct vaccination responses to polysaccharides have been documented in deficiencies of C3 [13,14] and properdin [14,34], a component of the alternative activation pathway, and might also be expected in classical pathway deficiency states.…”

Section: C2 Deficiency and Igm/igg Switching 557mentioning

confidence: 98%

Low Concentrations of Immunoglobulin G Antibodies to Salmonella Serogroup C in C2 Deficiency: Suggestion of a Mannan‐Binding Lectin Pathway‐Dependent Mechanism

et al. 1999

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The influence of complement on immune responses to polysaccharides is debatable. We examined the serum concentrations of IgM and IgG antibody against Salmonella O-antigen specific oligosaccharides representing the serogroups B, C and D, and against capsular polysaccharides of Streptococcus pneumoniae serotypes 6 and 23 in C2-deficient adults and in healthy controls. A sharp contrast of findings was found for antibodies against the CO antigen, an activator of the mannan-binding lectin (MBL) pathway of complement activation. The C2-deficient group showed normal IgM and markedly low IgG antibody levels. Similar findings were made in adults with low concentrations of MBL. This suggests that the recruitment of classical pathway C3 convertase through the MBL pathway is critically involved in isotype switching of antibodies against MBL pathway activating antigens during immune system maturation. The findings imply a new role of the MBL pathway, and an additional link between innate and acquired immunity. Specific IgM against BO was moderately low in C2 deficiency. Other differences for the Salmonella antigens were not found. Markedly raised IgM antibody levels against pneumococcal polysaccharides in C2 deficiency probably Salmonella reflected past infections. The absence of a concomitant increase of specific IgG might possibly be explained by impaired IgM to IgG switching.

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Section: C2 Deficiency and Igm/igg Switching 557mentioning

confidence: 98%

Low Concentrations of Immunoglobulin G Antibodies to Salmonella Serogroup C in C2 Deficiency: Suggestion of a Mannan‐Binding Lectin Pathway‐Dependent Mechanism

et al. 1999

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“…For instance, favorable in vitro responses to tetravalent meningococcal vaccination have been demonstrated in properdin deficiency and in late-complement component deficiencies [10,11,12]. Vaccination of C2D patients has been considered to be advisable despite a lack of supportive data [2,13].…”

Section: Haemophilus Influenzae Type B (Hib) However Gram-positive mentioning

confidence: 99%

Vaccination against encapsulated bacteria in hereditary C2 deficiency results in antibody response and opsonization due to antibody-dependent complement activation

Jönsson

Lood

Gullstrand

et al. 2012

Clinical Immunology

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“…Complement deficiencies are rare [64], and few studies investigate the impact of these deficiencies on vaccine success. In the largest of these studies, 53 patients with a variety of genetic complement deficiencies (properdin, Factor H, late components) were immunised with the tetravalent meningococcal polysaccharide vaccine ACYW135 [65].…”

Section: The Contribution Of Complement Activation Towards Vaccinatiomentioning

confidence: 99%

The role of complement in the success of vaccination with conjugated vs. unconjugated polysaccharide antigen

Salehen¹,

Stover²

2008

Vaccine

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The complement system, a well-characterised arm of the innate immune system, significantly influences the adaptive immune response via direct cell-cell interaction and maintenance of lymphoid organ architecture. Development of vaccines is a major advance in modern health care. In this review, we highlight the importance of the marginal zone in response to both, polysaccharide and conjugated vaccines, and discuss the relevance of complement herein, based on findings obtained from animal models with specific deletions of certain complement components and from vaccination reports of complement-deficient individuals. We conclude that both, intactness of the complement system and maturity of expression of its components, are relatively more important to aid in the immune response to polysaccharide vaccine than to conjugated vaccines. keywords (3): complement vaccine polysaccharide running titleComplement essential for polysaccharide vaccines 2 The importance of complement activation in adaptive immunityThe complement system is part of the innate immune defence, because it partakes in first-line, pattern-mediated recognition via its germ-line encoded serum proteins and receptors. It has evolved from a primordial fluid-phase system that "simply" tags and mediates uptake of micro-organisms by cells of early chordates. Large-scale gene duplications, exon shuffling and transposition events are the main evolutionary mechanisms that have generated a wide range of diversified molecules, which we now ascribe to innate and adaptive immune defences Importantly, after subcutaneous administration of T-independent or T-dependent antigens in mice, it is the spleen that reacts with formation of antibody forming cells before the draining lymphnodes, especially in response to T-independent antigen [32].Germinal centers are formed during an immune response elicited with a so-called Tindependent antigen. This reaction is, however, of short duration. It is possible that the absence of somatic hypermutation of the immunoglobulin V genes is due to both, the curtailed germinal center reaction -as somatic hypermutation is a relatively late event -6 and the lack of T-cell help [33]. Of note, marginal zone B-cells are incapable of participating in the process of somatic hypermutation due to the lack of expression of activation-induced cytidine deaminase, an enzyme essential for this process [34].The involvement of T-cells is not strictly excluded in the antibody response against polysaccharides, as B7 ligand dependent costimulation of B-cells (by T-cells) is needed, however, the interaction in this early response is short and T-cell receptor unspecific [35].The absence of somatic hypermutation does, however, explain the low affinity binding of anti-polysaccharide antibodies.

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Protection against meningococcal serogroup ACYW disease in complement-deficient individuals vaccinated with the tetravalent meningococcal capsular polysaccharide vaccine

Cited by 75 publications

References 27 publications

Low Concentrations of Immunoglobulin G Antibodies to Salmonella Serogroup C in C2 Deficiency: Suggestion of a Mannan‐Binding Lectin Pathway‐Dependent Mechanism

Low Concentrations of Immunoglobulin G Antibodies to Salmonella Serogroup C in C2 Deficiency: Suggestion of a Mannan‐Binding Lectin Pathway‐Dependent Mechanism

Vaccination against encapsulated bacteria in hereditary C2 deficiency results in antibody response and opsonization due to antibody-dependent complement activation

The role of complement in the success of vaccination with conjugated vs. unconjugated polysaccharide antigen

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