Protection against proximal tubule necrosis with 11-deoxy-16,16-dimethyl prostaglandin E<sub>2</sub> in vitro

Lee, H. Thomas

doi:10.1152/ajprenal.00276.2004

Cited by 3 publications

(2 citation statements)

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“…ATP depletion in kidney tubules after ischemic injury leads to cell death (Lee, 2004). Adenosine uptake mediates recovery of ATP content in postischemic cultured renal tubular cells (Cadnapaphornchai et al, 1991).…”

Section: Ischemiamentioning

confidence: 99%

Purinergic Signaling and Blood Vessels in Health and Disease

2013

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Section: Ischemiamentioning

confidence: 99%

Purinergic Signaling and Blood Vessels in Health and Disease

2013

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“…We hypothesized that PGE 2 , present in large quantities around cancer cells, affects uPA production from fibroblasts. In this study, using two lines of human lung fibroblasts, WI-38 and isolated human lung fibroblasts (IHLF), we investigated the effect of 11-deoxy-16, 16-dimethyl prostaglandin E 2 (DDM-PGE 2 ), a stable synthetic analogue of PGE 2 , on the uPA production of these fibroblasts [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effect of prostaglandin E₂on urokinase‐type plasminogen activator production by human lung fibroblasts

Odaka

Kobayashi

Takahashi

et al. 2009

Scandinavian Journal of Clinical and Laboratory Investigation

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Human lung fibroblasts are components of stromal tissue and produce various proteins as occasion demands, such as extracellular matrix (ECM) components and proteases. Pulmonary tumour cells produce high levels of prostaglandin E(2) (PGE(2)), which regulates tumour growth and metastasis. Urokinase-type plasminogen activator (uPA) is essential in the degradation of peritumour ECM. Furthermore, uPA is an important protease believed responsible for several tumour characteristics through its activation of certain proteases and growth factors. We hypothesized that the PGE(2) overexpression from tumour cells would have some effect on uPA expression in lung fibroblasts. In this study, the influence of PGE(2) on uPA expression in human lung fibroblasts was investigated using two lines of such fibroblasts. Although the cell surface uPA level was comparable to that of PGE(2) untreated cells, the expression of uPA mRNA and production was increased by the addition of PGE(2) in both lines of fibroblasts. These fibroblasts expressed both the EP(2) and EP(4) PGE(2) receptor mRNAs. Pretreatment with EP(2) and/or EP(4) receptor antagonists reduced the intercellular and cell surface uPA expression of the human lung fibroblasts. These results indicated that there is a relationship between the PGE(2) system and uPA production in human lung fibroblasts operating through EP(2) and/or EP(4) receptor signalling. uPA induced by PGE(2) from stromal fibroblasts surrounding lung tumour thus appears to play an important role through these EP receptors. Inhibition of EPs in tumour tissue might be a useful strategy for anti-metastasis therapy.

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N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis

Efrati

Berman

Siman-Tov

et al. 2007

Nephrology Dialysis Transplantation

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Protection against proximal tubule necrosis with 11-deoxy-16,16-dimethyl prostaglandin E₂ in vitro

Cited by 3 publications

References 20 publications

Purinergic Signaling and Blood Vessels in Health and Disease

Purinergic Signaling and Blood Vessels in Health and Disease

Effect of prostaglandin E₂on urokinase‐type plasminogen activator production by human lung fibroblasts

N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis

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Protection against proximal tubule necrosis with 11-deoxy-16,16-dimethyl prostaglandin E2 in vitro

Cited by 3 publications

References 20 publications

Purinergic Signaling and Blood Vessels in Health and Disease

Purinergic Signaling and Blood Vessels in Health and Disease

Effect of prostaglandin E2on urokinase‐type plasminogen activator production by human lung fibroblasts

N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis

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Product

Resources

About

Protection against proximal tubule necrosis with 11-deoxy-16,16-dimethyl prostaglandin E₂ in vitro

Effect of prostaglandin E₂on urokinase‐type plasminogen activator production by human lung fibroblasts