Protection against renal ischemia–reperfusion injury through hormesis? Dietary intervention versus cold exposure

Shushimita, Shushimita; Grefhorst, Aldo; Steenbergen, Jacobie; Bruin, Ron W. F. de; IJzermans, Jan N.M.; Themmen, Axel P. N.; Dor, Frank J. M. F.

doi:10.1016/j.lfs.2015.11.022

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…Gastric emptying was determined weekly, starting at 6‐8 weeks of age. Some mice were exposed to a cold stress test, which has been demonstrated to significantly accelerate gastric emptying . Cages containing these mice were placed in a 4°C walk‐in refrigerator for a period of 15 min ending 30 min prior to testing.…”

Section: Methodsmentioning

confidence: 99%

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High temporal resolution gastric emptying breath tests in mice

Miller

Bajzer

Hein

et al. 2018

Neurogastroenterology Motil

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Section: Methodsmentioning

confidence: 99%

“…Some mice were exposed to a cold stress test, which has been demonstrated to significantly accelerate gastric emptying. 21,22 Cages containing these mice were placed in a 4°C walk-in refrigerator for a period of 15 min ending 30 min prior to testing. Drugs or vehicle controls were delivered to mice via intraperitoneal (i.p.)…”

Section: Animalsmentioning

confidence: 99%

High temporal resolution gastric emptying breath tests in mice

Miller

Bajzer

Hein

et al. 2018

Neurogastroenterology Motil

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“…Hormesis is known by multiple names: preconditioning, conditioning, pretreatment, cross tolerance, and adaptive homeostasis [24]. Dietary restriction (DR), fasting (FA), and cold exposure (CE) are hormetic stress models [25]. Rapid stress hardening (RCH) is the fastest acclimatory response to low temperature known and it is a key adaptation for coping with thermal variability, especially for ectotherms such as crustaceans, terrestrial arthropods, amphibians, and reptiles.…”

Section: Evolutionary Origin 21 the Beginningsmentioning

confidence: 99%

Less Can Be More: The Hormesis Theory of Stress Adaptation in the Global Biosphere and Its Implications

Schirrmacher¹

2021

Biomedicines

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A dose-response relationship to stressors, according to the hormesis theory, is characterized by low-dose stimulation and high-dose inhibition. It is non-linear with a low-dose optimum. Stress responses by cells lead to adapted vitality and fitness. Physical stress can be exerted through heat, radiation, or physical exercise. Chemical stressors include reactive species from oxygen (ROS), nitrogen (RNS), and carbon (RCS), carcinogens, elements, such as lithium (Li) and silicon (Si), and metals, such as silver (Ag), cadmium (Cd), and lead (Pb). Anthropogenic chemicals are agrochemicals (phytotoxins, herbicides), industrial chemicals, and pharmaceuticals. Biochemical stress can be exerted through toxins, medical drugs (e.g., cytostatics, psychopharmaceuticals, non-steroidal inhibitors of inflammation), and through fasting (dietary restriction). Key-lock interactions between enzymes and substrates, antigens and antibodies, antigen-presenting cells, and cognate T cells are the basics of biology, biochemistry, and immunology. Their rules do not obey linear dose-response relationships. The review provides examples of biologic stressors: oncolytic viruses (e.g., immuno-virotherapy of cancer) and hormones (e.g., melatonin, stress hormones). Molecular mechanisms of cellular stress adaptation involve the protein quality control system (PQS) and homeostasis of proteasome, endoplasmic reticulum, and mitochondria. Important components are transcription factors (e.g., Nrf2), micro-RNAs, heat shock proteins, ionic calcium, and enzymes (e.g., glutathion redox enzymes, DNA methyltransferases, and DNA repair enzymes). Cellular growth control, intercellular communication, and resistance to stress from microbial infections involve growth factors, cytokines, chemokines, interferons, and their respective receptors. The effects of hormesis during evolution are multifarious: cell protection and survival, evolutionary flexibility, and epigenetic memory. According to the hormesis theory, this is true for the entire biosphere, e.g., archaia, bacteria, fungi, plants, and the animal kingdoms.

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“…Dietary restriction and fasting prevent or lessen the severity of cancer, and autoimmune diseases [71] caused changes in the development of B and T cells in primary and secondary lymphoid organs [72]. The protecting hormetic effect of mild air pollution against DNA damage does not interact with diet factors in lymphocytes of pregnant women [73].…”

Section: Effects Of Nutritionmentioning

confidence: 99%

Hormesis and immunity: A review

Csaba

2018

AMicr

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The hormesis concept demonstrates that in contrast to the toxic effect of high doses of materials, irradiation, etc., low doses of them are beneficial and, in addition, help to eliminate (prevent) the deleterious effect of high doses given after it. By this effect, it is an important factor of (human) evolution protecting man from harmful impacts, similarly to the role of immunity. However, immunity is also continuously influenced by hormetic effects of environmental [chemical (pollutions), physical (background irradiations and heat), etc.] and medical (drugs and therapeutic irradiations) and food interactions. In contrast to earlier beliefs, the no-threshold irradiation dogma is not valid in low-dose domains and here the hormesis concept is valid. Low-dose therapeutic irradiation, as well as background irradiations (by radon spas or moderately far from the epicenter of atomic bomb or nuclear facilities), is rather beneficial than destructive and the fear from them seems to be unreasonable from immunological point of view. Practically, all immune parameters are beneficially influenced by all forms of low-dose radiations.

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Protection against renal ischemia–reperfusion injury through hormesis? Dietary intervention versus cold exposure

Cited by 9 publications

References 33 publications

High temporal resolution gastric emptying breath tests in mice

High temporal resolution gastric emptying breath tests in mice

Less Can Be More: The Hormesis Theory of Stress Adaptation in the Global Biosphere and Its Implications

Hormesis and immunity: A review

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