Protection and reversion role of a pure stilbene extract from grapevine shoot and its major compounds against an induced oxidative stress

Medrano-Padial, Concepción; Puerto, María; Richard, Tristan; Cantos‐Villar, Emma; Pichardo, Silvia

doi:10.1016/j.jff.2021.104393

Cited by 7 publications

(3 citation statements)

References 70 publications

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“…In the present study, PIC directly decreased ROS levels, and co-treatment of NCM460 cells with PIC + B[ a ]P for 24 h significantly reduced the intracellular ROS levels induced by B[ a ]P (Figure A,C). GSH is a critical enzyme for the antioxidant reaction, and treatment with stilbenes has been reported to induce GSH content . B[ a ]P + PIC treatment significantly increased GSH levels compared with B[ a ]P alone, indicating that PIC exerts antioxidant effects in B[ a ]P-induced NCM460 cells by directly scavenging ROS and increasing GSH production (Figure B).…”

Section: Discussionmentioning

confidence: 89%

“…GSH is a critical enzyme for the antioxidant reaction, and treatment with stilbenes has been reported to induce GSH content. 47 B[a]P + PIC treatment significantly increased GSH levels compared with B[a]P alone, indicating that PIC exerts antioxidant effects in B[a]P-induced NCM460 cells by directly scavenging ROS and increasing GSH production (Figure 4B). In addition to ROS-based DNA damage, the activation of phase I metabolizing enzymes, such as CYP1A1 and CYP1B1, is a major mechanism in B[a]P-mediated carcinogenesis.…”

Section: Discussionmentioning

confidence: 94%

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Protective Effects of Piceatannol on DNA Damage in Benzo[a]pyrene-Induced Human Colon Epithelial Cells

Chang

Lien

Lin

et al. 2023

J. Agric. Food Chem.

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Evidence shows that the dietary intake of polycyclic aromatic hydrocarbons (PAHs) from food processing induces the cellular DNA damage response and leads to the development of colorectal cancer (CRC). Therefore, protecting from cellular DNA damage might be an effective strategy in preventing CRC. Benzo[a]pyrene (B[a]P) was used as a CRC initiator in the present study. Compared with other stilbenoids, piceatannol (PIC) showed the most effective inhibition of B[a]P-induced cytochrome P450 1B1 (CYP1B1) protein expression in NCM460 normal human colon epithelial cells. PIC treatment alleviated DNA migration and enhanced the expression of DNA-repair-related proteins, including histone 2AX (H2AX), checkpoint kinase 1 (Chk1), and p53, in B[a]P-induced NCM460 cells. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, flow cytometry, and enzyme-linked immunosorbent assay (ELISA) revealed that PIC exerted antioxidative effects on NCM460 cells by increasing the glutathione (GSH) content and scavenging the excess intracellular reactive oxygen species (ROS) induced by B[a]P. Furthermore, PIC suppressed B[a]P-induced CYP1B1 protein expression and stimulated miR-27b-3p expression. The upregulation of phase II detoxification enzymes, such as nicotinamide adenine dinucleotide phosphate (NADPH) and quinone oxidoreductase 1 (NQO1), and the antioxidative enzyme, heme oxygenase 1 (HO-1), via the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway was observed in the PIC-treated group. Our results suggest that PIC is a potential CRC-blocking agent due to its ability to alleviate DNA damage, decrease intracellular ROS production, modulate the metabolism and detoxification of B[a]P, and activate the Nrf2 signaling pathway in B[a]P-induced NCM460 cells.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 94%

Protective Effects of Piceatannol on DNA Damage in Benzo[a]pyrene-Induced Human Colon Epithelial Cells

Chang

Lien

Lin

et al. 2023

J. Agric. Food Chem.

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“…The anti-inflammatory and neuroprotective effects of stilbenes, especially resveratrol, have been confirmed in rodent models, with promising results also in terms of cognitive impairment recovery and amyloid plaque reduction [ 102 ]. An additional possible use of these compounds in the future is as natural additives to preserve food from oxidation, given their efficacy in these terms [ 107 ] and their non-genotoxicity as tested in vivo [ 108 ]. Finally, resveratrol has shown promise in treating human respiratory viral infections, given the antiviral activity reported against, to name a few, influenza virus, respiratory syncytial virus and SARS-CoV-2 [ 109 ].…”

Section: Polyphenols and Tanninsmentioning

confidence: 99%

Polyphenol and Tannin Nutraceuticals and Their Metabolites: How the Human Gut Microbiota Influences Their Properties

et al. 2022

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Nutraceuticals have been receiving increasing attention in the last few years due to their potential role as adjuvants against non-communicable chronic diseases (cardiovascular disease, diabetes, cancer, etc.). However, a limited number of studies have been performed to evaluate the bioavailability of such compounds, and it is generally reported that a substantial elevation of their plasma concentration can only be achieved when they are consumed at pharmacological levels. Even so, positive effects have been reported associated with an average dietary consumption of several nutraceutical classes, meaning that the primary compound might not be solely responsible for all the biological effects. The in vivo activities of such biomolecules might be carried out by metabolites derived from gut microbiota fermentative transformation. This review discusses the structure and properties of phenolic nutraceuticals (i.e., polyphenols and tannins) and the putative role of the human gut microbiota in influencing the beneficial effects of such compounds.

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Vitis Wastes as a Source of Stilbenes: Natural Occurrence, Factors Affecting Biosynthesis, and Valorization in Agri-Food Sector

Gabaston

Taillis

Cantos‐Villar

2023

Sustainable Development and Biodiversity

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Protection and reversion role of a pure stilbene extract from grapevine shoot and its major compounds against an induced oxidative stress

Cited by 7 publications

References 70 publications

Protective Effects of Piceatannol on DNA Damage in Benzo[a]pyrene-Induced Human Colon Epithelial Cells

Protective Effects of Piceatannol on DNA Damage in Benzo[a]pyrene-Induced Human Colon Epithelial Cells

Polyphenol and Tannin Nutraceuticals and Their Metabolites: How the Human Gut Microbiota Influences Their Properties

Vitis Wastes as a Source of Stilbenes: Natural Occurrence, Factors Affecting Biosynthesis, and Valorization in Agri-Food Sector

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