Protection by Cysteine Against the Acute Toxicity of a Chemical Radio‐sensitizer (“Synkavit”)

Phillips, Aimee; Cater, D. B.

doi:10.1111/j.1476-5381.1956.tb01040.x

Cited by 1 publication

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“…It seemed likely that M&B 16,573 might be hydrolysed in vivo to 2,6-dimethoxyphenol and morpholinopropionic acid 2,6-dimethoxyphenol 4-hydroxylation 2,6-dirnethoxyquinol 4-hydroxylation to form a quinol and the corresponding 2,6-dimethoxybenzoquinone, and that the latter might be a toxic metabolite. Phillips & Cater (1956) showed that sulphydryl-containing compounds protected against the acute toxicity of menadiol diphosphate (2-methyl-I : 4-naphthohydroquinone diphosphate) in rats. Hence, if the above hypothesis of the cause for the delayed toxicity of M&B 16,573 were correct, sulphydryl compounds might afford protection against this.…”

Section: Introductionmentioning

confidence: 99%

“…Phillips & Cater (1956) showed that sulphydryl-containing compounds protected against the acute toxicity of menadiol diphosphate (2-methyl-I : 4-naphthohydroquinone diphosphate) in rats. Hence, if the above hypothesis of the cause for the delayed toxicity of M&B 16,573 were correct, sulphydryl compounds might afford protection against this.…”

Section: Introductionmentioning

confidence: 99%

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The Prevention by Sulphydryl Compounds of the Toxicity in the Cat of 2,6‐dimethoxyphenol and Its Morpholinopropionyl Ester

Loveless¹,

Maxwell²

1975

British J Pharmacology

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Intravenous (—)‐2,6‐dimethoxyphenyl‐2‐morpholinopropionate hydrochloride (M&B 16,573) produced anaesthesia of short duration in the mouse, rat, rabbit, cat, dog and monkey. In the cat but not in other species, a severe and usually fatal toxic reaction was seen 1‐2 h after administration. This toxic reaction but not the anaesthetic properties of M&B 16,573 was prevented by the intravenous administration of cysteine or N‐acetylcysteine. Cysteamine or dimercaprol were ineffective. Intravenous administration of 2,6‐dimethoxyphenol or 2,6‐dimethoxyquinol in the cat produced a response similar to the delayed toxic effects of M&B 16,573 but not preceded by anaesthesia. The toxic effects of these compounds were prevented by cysteine. Intravenous 4‐allyl‐2,6‐dimethoxyphenyl‐2‐morpholinoprop*ionate hydrochloride produced anaesthesia in the cat without the delayed toxic effects seen after M&B 16,573. The acute toxicity of 2,6‐dimethoxyquinol in mice was reduced by the administration of cysteine or N‐acetylcysteine. It is postulated that the delayed effects produced by M&B 16,573 in the cat are due to the formation of 2,6‐dimethoxyquinol and 2,6‐dimethoxybenzoquinone in this species, the toxicity of the latter being reduced by sulphydryl compounds.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%