Protection by glutathione of neutrophils against the toxic effects of peritoneal dialysis fluid

Yahyapour, Noushin; Eriksson, Cecilia; Kjellstrand, Per; Wieslander, Anders; Nygren, Håkan

doi:10.1016/s0887-2333(01)00073-x

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…We have previously shown that acute in vitro exposure of mesothelial cells to a standard dialysis solution results in transient decreases in intracellular glutathione and that OTZ not only prevented this effect but even augmented the concentration of glutathione in these cells [17]. Yahyapour et al [18] found that glutathione reduced the cytotoxic effect of heat-sterilized peritoneal dialysis fluid on neutrophils. However, it is possible that addition of reduced glutathione to the dialysis fluid may be impractical because of the rapid oxidation of this substance into its inactive oxidized form.…”

Section: Discussionmentioning

confidence: 98%

L-2-Oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products

Bręborowicz¹,

Witowski²,

Połubińska³

et al. 2004

Nephrology Dialysis Transplantation

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Section: Discussionmentioning

confidence: 98%

L-2-Oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products

Bręborowicz¹,

Witowski²,

Połubińska³

et al. 2004

Nephrology Dialysis Transplantation

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“…Another significant problem to be considered is that of dialysate inhibition of leukocyte function. While it is not totally clear that the effect is due to the carboxylic acids (27,62–67), bicarbonate‐based solutions do have superior neutrophil and macrophage viability (16,68), and, like the toxicity seen in bacteria, the effect also appears related to the ability of organic acids to lower intracellular pH (69).…”

Section: Adverse Effects Of Carboxylic Acid Salts On the Patients' Cellsmentioning

confidence: 99%

Lessons From Single Cell Organisms: Insights Into the Antimicrobial and Toxic Effects of Peritoneal Dialysate Bases

Diskin

2010

Ther Apher Dial

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Although it was first described over a quarter of a century ago, the mechanisms behind the antimicrobial activity of fresh peritoneal dialysate have been poorly understood. Recent insight into the biochemistry appears to suggest that at least part of the effect resides in the salts of the carboxylic acids. An understanding of the metabolic pathways of both sensitive and resistant organisms has not only led to an understanding of the mechanisms of the antimicrobial effect, but also may have provided the insight for future studies to reduce toxicity to the peritoneal membrane. While our knowledge base in this area is still evolving, an improved understanding of the biochemical basis of both the antibacterial effect and toxicity of the salts of carboxylic acids in peritoneal dialysate can only prove useful.

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“…[24][25][26][27] Despite their very similar structure, diversity was revealed, e.g. in the ability of these luminophores to reduce NADPH oxidase activity 21 or in the quality of luminol and isoluminol chemiluminescence signal.…”

Section: Luminol and Isoluminol Are Different In The Light Of Their Amentioning

confidence: 99%

The combined luminol/isoluminol chemiluminescence method for differentiating between extracellular and intracellular oxidant production by neutrophils

et al. 2006

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To address the question why isoluminol, but not luminol, failed to detect oxidants produced intracellularly, differences between these luminophores were investigated with respect to physicochemical parameters and the character of chemiluminescence signal. Our results showed the isoluminol molecule to be more polar, more hydrophilic and possessing lower ability to form intramolecular bonds than the luminol molecule. Therefore, isoluminol: (i) only slightly pervaded biological membranes; (ii) depended essentially on extracellular peroxidase; (iii) did not produce chemiluminescence in the presence of extracellular scavengers; and (iv) it could be considered a specific detector of extracellular radicals. On the other hand, the physicochemical parameters of luminol and partial resistance of its chemiluminescence to the effect of extracellular inhibitors proved the lipo/hydrophilic character of this luminophore and thus its ability to interact with radicals both outside and inside of cells. The luminol chemiluminescence measured in the presence of extracellular scavengers and the isoluminol chemiluminescence were used with the intention to differentiate the effects of two antihistamine drugs on intra- and extracellular radical formation. In activated human neutrophils, brompheniramine inhibited the extracellular and potentiated the intracellular part of chemiluminescence signal, whereas a reducing effect of loratadine was observed in both compartments.

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Protection by glutathione of neutrophils against the toxic effects of peritoneal dialysis fluid

Cited by 5 publications

References 20 publications

L-2-Oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products

L-2-Oxothiazolidine-4-carboxylic acid reduces in vitro cytotoxicity of glucose degradation products

Lessons From Single Cell Organisms: Insights Into the Antimicrobial and Toxic Effects of Peritoneal Dialysate Bases

The combined luminol/isoluminol chemiluminescence method for differentiating between extracellular and intracellular oxidant production by neutrophils

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