Protection by Liquorice in Alcohol Induced Gastric Mucosa Damage

Ligha, AE; Fawehinmi, H. B.

doi:10.3923/pjn.2009.1532.1536

Cited by 8 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…( Carvalho et al, 2010 ), Parkia platycephala Benth. ( Fernandes et al, 2010 ), Glycyrrhiza glabra L. ( Ligha and Fawehinmi, 2009 ) and Carica papaya L. ( Ologundudu et al, 2008 ) possessed antioxidant effect in the ethanol-induced gastric damage.…”

Section: Resultsmentioning

confidence: 99%

Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants

El‐Meligy

Awaad

Soliman

et al. 2017

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

The present study aimed to evaluate the anti-ulcerogenic activities and the possible mechanisms of action of seven desert plants from different families. (L.) Desf. (Asteraceae), L. (Euphorpiaceae), L., lanigera L. (Lamiaceae), L., Linn. (Solanaceae) and (Del.) Hayne. (Asclepiadaceae), were tested using prophylactic and curative models of absolute ethanol-induced ulcer, at three doses (125, 250& 500 mg/kg) of each extract. The investigated extracts possessed dose dependent anti-ulcerogenic activities in both models, with LD higher than 5 g/kg. The most effective extracts were and with percent protection of control ulcer; 91.1% and 85.4% respectively. The antisecretory activity of both and appears to be mainly related to the suppression of gastrin release. The potential radical (DPPH) scavenging activities of the investigated extracts were well supported with the reduction in gastric MDA (50.6% and 43.3%) and enhancing the level of reduced GSH (2.84, 2.59 mg/g tissue) for and respectively. In addition, suppression of the inflammatory mediator TNF-α may be one of the possible mechanisms of action. The alcohol extracts of and showed no alteration on liver and kidney functions. Phytochemical screening of the investigated extracts revealed the presence of flavonoids, tannins and sterols which could be related to the activities.

show abstract

Section: Resultsmentioning

confidence: 99%

Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants

El‐Meligy

Awaad

Soliman

et al. 2017

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

show abstract

“…Pharmacologically does they suppress acid secretion [18], stimulate secretion of mucus and bicarbonate [19,20] and protect the gastric mucosa against the harmful effects of salicylates [21], bile acid [22] and ethanol [23]. Their effects on gastrin release are controversial; they have been variously reported to decrease [24] or have no effect on [25] serum gastrin concentration.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of HEAC and its Primary Active Compound on HCl-ethanol Induced Gastritis in Rats

Choi¹,

Jang²,

Lee³

et al. 2012

Journal of the Korea Academia-Industrial cooperation Society

View full text Add to dashboard Cite

The purpose of this study is to evaluate the gastric mucosal damage effect by Hericium erinaceus cultibated with Artemisia capillaris (HEAC) with 0.15 M HCl in ethanol in rats. Among them, 80% ethanol extract showed potent inhibitory effect (67.7%) on gastritis. Using solvent fractionation, 80% ethanol extract of HEAC was separated into five fractions with n-hexane, methylene chloride, ethyl acetate, n-butanol and water. As a result, fractions obtained with methylene chloride exhibited strong inhibitory effects on gastritis. With this result, the methylene chloride extract was analyzed by GC/MS, HPLC, IR and NMR(

show abstract

“…[ 13 ], Parkia platycephala Benth. [ 23 ], Glycyrrhiza glabra L. [ 24 ] and C arica papaya L. [ 25 ].…”

Section: Plant and Their Products With Anti-ulcer Activitymentioning

confidence: 99%

Protection by Liquorice in Alcohol Induced Gastric Mucosa Damage

Cited by 8 publications

References 11 publications

Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants

Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants

Protective Effects of HEAC and its Primary Active Compound on HCl-ethanol Induced Gastritis in Rats

Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective

Contact Info

Product

Resources

About