Protection by N-acetylcysteine against pulmonary endothelial cell damage induced by oxidant injury

Sala, Roberto; Moriggi, Ermanno; Corvasce, G; Morelli, Daniele

doi:10.1183/09031936.93.06030440

Cited by 37 publications

(3 citation statements)

References 27 publications

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“…NAC is a glutathione precursor that is commonly used as an antidote for acetaminophen overdose. In addition to augmenting glutathione synthesis, NAC has oxygen radical scavenging properties, 43 and NAC therapy has been examined in several clinical studies of ARDS patients with modest but encouraging results. In one trial of 66 patients with ARDS, NAC therapy was associated with a small increase in lung compliance compared with the control group but did not affect the survival rate.…”

Section: Potential Therapies For Alcohol-associated Lung Injurymentioning

confidence: 99%

Alcohol Abuse and Acute Lung Injury: Epidemiology and Pathophysiology of a Recently Recognized Association

Guidot

Hart

2005

Journal of Investigative Medicine

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Alcohol is the most commonly used and abused drug in the United States. The deleterious health effects of alcohol can be attributed both to its acute intoxicating effects, which result in temporary impairment of judgment and motor skills, and to its more chronic and toxic effects on the liver, pancreas, heart, and brain, all of which may result in irreversible organ damage. Although recognized for more than a century as a major risk factor for pneumonia, alcohol abuse was until recently perceived to have no significant effects on lung structure and/or function. However, within the past decade, epidemiologic studies have revealed that alcohol abuse independently increases the risk of acute respiratory distress syndrome (ARDS) two- to fourfold in patients with sepsis or trauma and may play a role in ARDS pathogenesis in as many as half of all patients with the syndrome. Although alcohol abuse alone does not cause acute lung injury, it renders the lung susceptible to dysfunction in response to the inflammatory stresses of sepsis, trauma, and other clinical conditions recognized to cause ARDS. Recent investigations in both animal models of chronic ethanol ingestion and in human subjects with a history of alcohol abuse have explored this previously unrecognized connection between alcohol and acute lung injury and have uncovered multiple derangements, which we now characterize as the "alcoholic lung." This review summarizes the epidemiologic association between alcohol abuse and acute lung injury and the recent experimental findings that are unraveling the underlying pathophysiology.

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Section: Potential Therapies For Alcohol-associated Lung Injurymentioning

confidence: 99%

Alcohol Abuse and Acute Lung Injury: Epidemiology and Pathophysiology of a Recently Recognized Association

Guidot

Hart

2005

Journal of Investigative Medicine

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“…A deficiency in the activity of endothelial NOS may be responsible for pulmonary hypertension. It has been suggested that ROS may initiate pulmonary hypertension during ascites as vascular endothelial cells are the primary targets of oxidant injury (Sala et al, 1993). ROS deactivates NO and inhibits the activity of NOS (Rengasamy and Johns, 1993).…”

Section: Discussionmentioning

confidence: 99%

Effect of Low Ambient Temperature on the Concentration of Free Radicals Related to Ascites in Broiler Chickens

Han¹,

Yoon²,

Han³

et al. 2005

Asian Australas. J. Anim. Sci

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A flock of Arbor Acres chickens were reared in cages and provided with high energy pelleted feed. At 14 d of age, a total of 350 birds were separated into 3 groups randomly as follows: 100 birds were exposed to ambient temperature of 20°C as a control group, 150 birds were exposed to lower ambient temperature of 11°C to induce ascites (group I), and another group of 100 birds were exposed to lower ambient temperature of 11°C and fed diet containing 1% L-arginine for ascitic prophylactic treatment (group II). Blood and tissue samples (lung and liver) were collected from chickens at 3, 4, 5, 6 and 7 wk of age subsequently, to analyze the concentration and activities of free radicals, mononaldehyde (MDA), superoxide dismutase (SOD), Nitric Oxide (NO) and Nitric oxide synthase (NOS). The results showed that the prevalence of ascites in the control, group I and group II was 3%, 9.33% and 3% respectively (p<0.01). The concentration of free radicals in the lungs of 3 wks old preascitic broilers in group I was significantly higher than in the corresponding control group (p<0.05). The concentrations of free radicals in lung and liver in the 7 wk period, and that of NO and SOD in the plasma were significantly lower in group I than in the control group (p<0.01). However, the accumulated MDA contents in group I were higher than in the control group and group II (p<0.05), respectively. In the same way, the activity of NOS in group II was higher than both group I and control group (p<0.01) during the 7 wk period. There was no significant difference between SOD activities of group II and the control group (p>0.05), and also insignificant difference between NOS in group I and the control group (p>0.05). The results of this study indicate that there was a significant decrease in the concentration of MDA in group II. On the other hand, the concentration of free radicals decreased and MDA concentration increased in group I during the 7 wk period. The reduction in concentration of MDA in group II, following arginine supplementation may be associated with the scavenging activity of NO.

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“…In this issue of the journal, SALA et al [25] rep01t on the protective effect of NAC against oxidant lung injury induced by intrapulmonary immune complex deposition in rats. Serotonin uptake in the perfused lung served as a biochemical marker for pulmonary endothelial ceU function.…”

Section: K L Maier*mentioning

confidence: 99%

How the lung deals with oxidants

Maier¹

1993

Eur Respir J

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Protection by N-acetylcysteine against pulmonary endothelial cell damage induced by oxidant injury

Cited by 37 publications

References 27 publications

Alcohol Abuse and Acute Lung Injury: Epidemiology and Pathophysiology of a Recently Recognized Association

Alcohol Abuse and Acute Lung Injury: Epidemiology and Pathophysiology of a Recently Recognized Association

Effect of Low Ambient Temperature on the Concentration of Free Radicals Related to Ascites in Broiler Chickens

How the lung deals with oxidants

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