Protection from radiation-induced damage to spermatogenesis in the androgen pretreated rat

Schlappack, O; Delic, Julian I.; Harwood, Janet R.; Stanley, Judith A.

doi:10.1016/0167-8140(88)90264-2

Cited by 14 publications

(4 citation statements)

References 20 publications

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“…The weight of the testis is largely dependent on the mass of differentiated spermatogenic cells and it has been used as a measure of spermatogenesis in rats (Schlappack et al 1988). A positive correlation was observed between weight of testis and number of germ cells (Sinha Hikkim et al 1989).…”

Section: Discussionmentioning

confidence: 99%

Reduced Spermatogenesis in Rats Exposed Transplacentally to Hydroxyprogesterone

et al. 2003

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Summary Prenatal exposure to hydroxyprogesterone can alter the spermatogenesis in adult rat. For the purpose of assessing the effects of prenatal exposure to hydroxyprogesterone on postnatal reproductive performance, rats were treated intraperitoneally with doses of hydroxyprogesterone (10, 25 mg/kg body weight) on 1 st , 7 th and 14 th day of gestation. The reproductive performance of the male offspring was assessed after 90 d by determining the changes in testis weight and the number of spermatids. A significant (pϽ0.001) decrease in testicular weight and number of spermatids was observed in the experimental male rats. Testis of the experimental rats also exhibited symptoms of arrest of spermatogenesis. It is suggested that in utero exposure to supra-normal levels of hydroxyprogesterone affects male reproduction by altering the spermatogenesis.

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Section: Discussionmentioning

confidence: 99%

Reduced Spermatogenesis in Rats Exposed Transplacentally to Hydroxyprogesterone

et al. 2003

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“…(546) The use of hormonal suppression for fertility preservation in males receiving radiation and other cytotoxic therapies has been reviewed (Table 3.1) . It was shown that suppression of gonadotropin and intratesticular testosterone levels, using testosterone prior to or during exposure of rats to radiation, enhanced the subsequent recovery of spermatogenesis (Schlappack et al, 1988). Enhanced recovery was also found using oestradiol or a GnRH antagonist after 6 Gy (Shetty et al, 2004).…”

Section: Male Reproductive Systemmentioning

confidence: 99%

ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context

Stewart¹,

Akleyev²,

et al. 2012

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This report provides a review of early and late effects of radiation in normal tissues and organs with respect to radiation protection. It was instigated following a recommendation in Publication 103 (ICRP, 2007), and it provides updated estimates of 'practical' threshold doses for tissue injury defined at the level of 1% incidence. Estimates are given for morbidity and mortality endpoints in all organ systems following acute, fractionated, or chronic exposure. The organ systems comprise the haematopoietic, immune, reproductive, circulatory, respiratory, musculoskeletal, endocrine, and nervous systems; the digestive and urinary tracts; the skin; and the eye. Particular attention is paid to circulatory disease and cataracts because of recent evidence of higher incidences of injury than expected after lower doses; hence, threshold doses appear to be lower than previously considered. This is largely because of the increasing incidences with increasing times after exposure. In the context of protection, it is the threshold doses for very long follow-up times that are the most relevant for workers and the public; for example, the atomic bomb survivors with 40-50years of follow-up. Radiotherapy data generally apply for shorter follow-up times because of competing causes of death in cancer patients, and hence the risks of radiation-induced circulatory disease at those earlier times are lower. A variety of biological response modifiers have been used to help reduce late reactions in many tissues. These include antioxidants, radical scavengers, inhibitors of apoptosis, anti-inflammatory drugs, angiotensin-converting enzyme inhibitors, growth factors, and cytokines. In many cases, these give dose modification factors of 1.1-1.2, and in a few cases 1.5-2, indicating the potential for increasing threshold doses in known exposure cases. In contrast, there are agents that enhance radiation responses, notably other cytotoxic agents such as antimetabolites, alkylating agents, anti-angiogenic drugs, and antibiotics, as well as genetic and comorbidity factors. Most tissues show a sparing effect of dose fractionation, so that total doses for a given endpoint are higher if the dose is fractionated rather than when given as a single dose. However, for reactions manifesting very late after low total doses, particularly for cataracts and circulatory disease, it appears that the rate of dose delivery does not modify the low incidence. This implies that the injury in these cases and at these low dose levels is caused by single-hit irreparable-type events. For these two tissues, a threshold dose of 0.5Gy is proposed herein for practical purposes, irrespective of the rate of dose delivery, and future studies may elucidate this judgement further.

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“…e weight of the testis is mainly dependent on the mass of differentiated spermatogenic cells, and it has been used as a measure of spermatogenesis in rats [2]. A positive correlation between the weight of testis and the number of germ cells also was observed [8,23]. e present study also included the effect of prenatal progesterone treatment on the reproductive hormones, namely testosterone, LH, and FSH serum levels.…”

Section: Discussionmentioning

confidence: 85%

Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats

Ahmed

Magzoub

Al-Ayed

et al. 2020

International Journal of Endocrinology

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This study was designed to investigate the effect of prenatal exposure to synthetic sex steroid on sperm quantity and quality, relative testicular and epididymal weights, and reproductive hormones level in adult Wistar rats. Forty male Wistar rats were divided into two groups: a test group (n = 20) that included mature rats that were born to dams exposed to gestational treatment with hydroxyprogesterone and a control group (n = 20) that included mature rats born to untreated dams. Compared to the control group, the test group showed a significant reduction in the sperm count, viability and motility, relative testicular and epididymal weights together with increased abnormal spermatozoa (p<0.001). The reproductive hormonal assay revealed significantly lower serum testosterone and higher levels of FSH and LH among the test groups compared to the control (p<0.05 for all). Prenatal exposure to synthetic progesterone negatively affected sperm production and function, relative testicular and epididymal weights, and reproductive hormone levels.

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Protection from radiation-induced damage to spermatogenesis in the androgen pretreated rat

Cited by 14 publications

References 20 publications

Reduced Spermatogenesis in Rats Exposed Transplacentally to Hydroxyprogesterone

Reduced Spermatogenesis in Rats Exposed Transplacentally to Hydroxyprogesterone

ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context

Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats

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