Protection from vascular endothelial dysfunction in acute glycemic load-induced primary hypertension by vitamin C and E

Xu, Junxia; Su, Li-Ying; Chen, L; Lin, Jinxiu

doi:10.4238/2014.september.5.9

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…Nevertheless, there are some controversial results around this matter and some authors state that vitamin D supplementation have not been demonstrated to improve endothelial function in overweight/obese non-hypertensive individuals 21 . In contrast, a protective role of vitamin E supplementation on vascular endothelial function has been described, especially in hypertensive patients 22 .…”

Section: Discussionmentioning

confidence: 97%

Relevance of control diet choice in metabolic studies: impact in glucose homeostasis and vascular function

González-Blázquez

Alcalá

Fernández-Alfonso

et al. 2020

Sci Rep

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The experimental approach for the study of cardiometabolic disorders requires the use of animal models fed with commercial diets whose composition differs notably, even between diets used for control groups. While chow diets are usually made of agricultural by-products, purified low-fat diets (LF) contain a higher percentage of easy metabolizable carbohydrates, together with a reduced amount of polyunsaturated fatty acids, micronutrients and fiber, all associated with metabolic and vascular dysfunction. We hypothesize that the LF diet, commonly used in control animals, could promote adverse vascular and metabolic outcomes. To address this issue, 5-week-old male C57BL6J mice were fed with a standard (Chow) or a LF diet for 6 weeks. Changes in body weight, adiposity, biochemical parameters, systemic and aortic insulin sensitivity and endothelial function were recorded. LF diet did not modify body weight but significantly impaired systemic glucose tolerance and increased triglycerides and cholesterol levels. Endothelial function and aortic insulin sensitivity were significantly impaired in the LF group, due to a reduction of NO availability. These findings highlight the importance of selecting the proper control diet in metabolic studies. It may also suggest that some cardiometabolic alterations obtained in experimental studies using LF as a control diet may be underestimated.

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Section: Discussionmentioning

confidence: 97%

Relevance of control diet choice in metabolic studies: impact in glucose homeostasis and vascular function

González-Blázquez

Alcalá

Fernández-Alfonso

et al. 2020

Sci Rep

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show abstract

“…SBP, DBP ⬇, endothelial vasodilation ⬆ and arterial stiffness ⬇ [157,158]. Humans, essential hypertension [176].…”

Section: Vitamin C and Ementioning

confidence: 99%

Oxidative Stress, Antioxidants and Hypertension

et al. 2023

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As a major cause of morbidity and mortality globally, hypertension remains a serious threat to global public health. Despite the availability of many antihypertensive medications, several hypertensive individuals are resistant to standard treatments, and are unable to control their blood pressure. Regulation of the renin-angiotensin-aldosterone system (RAAS) controlling blood pressure, activation of the immune system triggering inflammation and production of reactive oxygen species, leading to oxidative stress and redox-sensitive signaling, have been implicated in the pathogenesis of hypertension. Thus, besides standard antihypertensive medications, which lower arterial pressure, antioxidant medications were tested to improve antihypertensive treatment. We review and discuss the role of oxidative stress in the pathophysiology of hypertension and the potential use of antioxidants in the management of hypertension and its associated organ damage.

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“…Only randomized trials with a low risk of bias were included in the study. The quality assessment tools used for cross-sectional [12][13][14], cohort [15][16][17][18][19][20][21][22][23][24][25], and case-control studies [26][27][28][29][30] were the Newcastle-Ottawa Quality Assessment Tool for cross-sectional, cohort, and casecontrol studies, respectively. A score of greater than or equal to seven stars during the individual quality assessment, as shown in Table 3, was included in the study.…”

Section: Figure 1: Prisma Flow Diagram Showing Data Extraction Processmentioning

confidence: 99%

A Systematic Review of Effects of Vitamin E on the Cardiovascular System

Shah

Shiekh

Lawrence

et al. 2021

Cureus

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Vitamin E is a fat-soluble vitamin and an antioxidant that prevents the peroxidation of lipid in vitro. The antioxidant role of vitamin E in preventing adverse cardiovascular outcomes is controversial as some studies support it, while others reject it. Therefore, this review aims to determine whether there is an association between vitamin E and cardiovascular diseases (CVDs). An electronic search was done to find out relevant articles. Papers were shortlisted after the initial title and abstract screen. A full-text study was done, and inclusion and exclusion criteria were applied before the quality assessment of each paper was done. Only high-quality papers were selected for analysis. Full-text articles of the last ten years were included, while non-English articles, gray literature, and animal studies were excluded. The majority of the papers, including 75% of the total population in this review, suggested no role of vitamin E in preventing CVD and CVD mortality. Some studies also suggested that a high level of vitamin E can be associated with adverse cardiovascular outcomes. Thus, one should be prudent about taking vitamin E supplementation for cardiovascular risk prevention.

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Protection from vascular endothelial dysfunction in acute glycemic load-induced primary hypertension by vitamin C and E

Cited by 5 publications

References 35 publications

Relevance of control diet choice in metabolic studies: impact in glucose homeostasis and vascular function

Relevance of control diet choice in metabolic studies: impact in glucose homeostasis and vascular function

Oxidative Stress, Antioxidants and Hypertension

A Systematic Review of Effects of Vitamin E on the Cardiovascular System

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