2006
DOI: 10.1016/j.vaccine.2006.02.012
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Protection induced in mice against a lethal orthopox virus by the Lister strain of vaccinia virus and modified vaccinia virus Ankara (MVA)

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Cited by 23 publications
(28 citation statements)
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“…Mice were euthanized 30 days p.i. and blood samples were collected for neutralization tests (NT); these were carried out using purified VACV-WR intracellular mature virus (Abdalrhman et al, 2006). Animal experimentation was carried out in accordance with regulations and guidelines of Ethical and Animal Use Committee of Universidade Federal de Minas Gerais, Brazil.…”
mentioning
confidence: 99%
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“…Mice were euthanized 30 days p.i. and blood samples were collected for neutralization tests (NT); these were carried out using purified VACV-WR intracellular mature virus (Abdalrhman et al, 2006). Animal experimentation was carried out in accordance with regulations and guidelines of Ethical and Animal Use Committee of Universidade Federal de Minas Gerais, Brazil.…”
mentioning
confidence: 99%
“…All rounds of transmission followed the same protocol described above. All uninfected mice were previously tested by NT to confirm OPV seronegativity (Abdalrhman et al, 2006). Faecal samples from sentinel mice were collected for 10 days p.e.…”
mentioning
confidence: 99%
“…Moreover, the immunogenicity of MVA is thought to be equivalent to that of conventional smallpox vaccines (13,21,27). MVA also displays reduced virulence in animals (1,31,37), and clinical trials in West Germany in the 1970s demonstrated it has an excellent safety profile in humans (19). MVA is therefore considered more suitable for immunocompromised individuals, children, or those with skin conditions such as atopic dermatitis, for whom conventional vaccines are contraindicated.…”
mentioning
confidence: 99%
“…We characterized the virus population comprising the Lister stock, used in Israel for many years for vaccination against smallpox. This stock was found to be heterogeneous and contained a mixture of viruses, forming plaques of different diameter in tissue cultures [13]. Three variants of the Lister stock were isolated and plaque purified: large plaque (LP), middle plaque (MP) and small plaque (SP); their different diameter in the plaque assay is clearly visible [13].…”
Section: Introductionmentioning
confidence: 99%
“…This stock was found to be heterogeneous and contained a mixture of viruses, forming plaques of different diameter in tissue cultures [13]. Three variants of the Lister stock were isolated and plaque purified: large plaque (LP), middle plaque (MP) and small plaque (SP); their different diameter in the plaque assay is clearly visible [13]. Furthermore, initial studies which we performed showed that Previously we found that C-terminal truncation of 35 amino acids in the A33R envelope protein of vaccinia virus causes enhanced release of extracellular virions from infected cells at the completion of the growth cycle of the virus, and also to significant attenuation of the virus for mice [14].…”
Section: Introductionmentioning
confidence: 99%