Protection of Ca++ transport by carnosine against disturbances induced by lipid peroxidation

Дупин, А. М.; Boldyrev, A. A.; Arkhipenko, Yu. V.; Kagan, V. E.

doi:10.1007/bf01262466

Cited by 19 publications

(16 citation statements)

References 3 publications

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“…The results suggest that carnosine may increase nerve transmission and reduce lipid peroxidation. 53 levels of antioxidants (GSH-Px and total antioxidant capacity) in those with osteoporosis in comparison with those without this condition. 37 Recently, antioxidant activity and the levels of lipid peroxidation have been examined in the elderly and adults resident in both rural and urban areas.…”

Section: Sources Of Endogenous Reactive Substancesmentioning

confidence: 99%

Association between oxidative stress and nutritional status in the elderly

Moreira

Bôas

Ferreira

2014

Rev. Assoc. Med. Bras.

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Ageing is a dynamic and progressive process that is characterized by the occurrence of morphological, biochemical, functional and psychological changes in the organism. The aim of the present article is to provide updated concepts on oxidative stress, covering its importance in aging, as well as nutritional status and supplementation with antioxidants (substances that prevent or attenuate oxidation of oxidizable substrates, such as lipids, proteins, carbohydrates and deoxyribonucleic acid) in the geriatric population. Evidence suggests that there is an inverse relationship between oxidative stress and nutritional status in elderly individuals. Although an increase in oxidative stress in chronic diseases associated with aging has been proven, such as Parkinson’s disease and Alzheimer’s disease, up to now there has been no consistent clinical evidence proving the efficiency of supplementation with antioxidants against oxidative stress. In this context, supplementation is not recommended. On the other hand, the elderly should be encouraged to eat antioxidant foods, such as fruits and vegetables. Maintaining a normal weight (body mass index between 23 and 28 Kg/m2) should also be stimulated.

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Section: Sources Of Endogenous Reactive Substancesmentioning

confidence: 99%

Association between oxidative stress and nutritional status in the elderly

Moreira

Bôas

Ferreira

2014

Rev. Assoc. Med. Bras.

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“…24 However, in this study, we found that carnosine applied 10 min before OGD did not provide any beneficial effect on mast cell degranulation, histamine and LDH release (data not shown), whereas carnosine applied 18 h before OGD markedly attenuated ischemic injury of mast cells. So the protective effect of carnosine on mast cell injury induced by OGD is probably due to its other biological roles, such as regulating transcription and expression of special proteins, 25 resisting reactive oxygen species (ROS) formation 26 and prevention of cytosolic free calcium overload during OGD, 27 but not to interaction with cell receptors, such as histamine receptors expressed on mast cells. However, the actual mechanism of the carnosine action on ischemic injury of mast cells is complex and further studies are needed in the future.…”

Section: Resultsmentioning

confidence: 99%

Carnosine attenuates mast cell degranulation and histamine release induced by oxygen–glucose deprivation

Shen

Zhang

et al. 2007

Cell Biochemistry & Function

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Carnosine (beta-alanyl-histidine) is a naturally occurring dipeptide that has been characterized as a putative hydrophilic antioxidant. The protective function of carnosine has been demonstrated in neuronal cells under ischemic injury. The purpose of this study was to investigate the effects of carnosine on oxygen-glucose deprivation (OGD)-induced degranulation and histamine release from mast cells. Cultured mast cells were exposed to OGD for 4 h, and then the degranulation was observed immediately by microscopy. Histamine release was analyzed by high-performance liquid chromatography (HPLC). OGD caused degranulation of mast cells, and increased histamine and lactate dehydrogenase (LDH) release. Carnosine (at a concentration of 5 mM) alone did not produce any appreciable effect on degranulation, histamine, and LDH release from mast cells under normal condition, but significantly inhibited the degranulation, histamine, and LDH release of mast cells induced by OGD. These results indicate that carnosine can protect mast cells from degranulation and histamine release and it may be an endogenous mast cell stabilizer in the pathological processes induced by ischemia.

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“…Carnosine also inhibits the oxidative hydroxylation of deoxyguanosine induced by ascorbic acid and copper ions [Kohen et al, 19881. In experiments with perfused muscle and with muscle extracts, carnosine lessens lipid peroxidation and alleviates muscle fatigue [Whitaker and Louw, 1984;Dupin et al, 1985Dupin et al, , 1987Boldyrev et al, 19881. Copper chelates of carnosine and other histidine-containing peptides possess superoxide dismutase activity [Brigelius et al, 1974;Gulyaeva, 19881. L-Carnosine administered i.p.…”

Section: -Carnosine (Merck #1834) and 1-histidine (Merck #4617)mentioning

confidence: 98%

Antimutagens and anticarcinogens: A survey of putative interceptor molecules

Hartman¹,

Shankel²

1990

Environ and Mol Mutagen

248

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In this review recent publications are cited for a number of antimutagens. The molecules surveyed are potential or proven "desmutagens" or "interceptors." These are biologically prevalent or synthetic molecules that are most often small metabolites proficient in binding to, or reacting with, mutagenic chemicals and free radicals. Many of this class of "blocking agents" are "soft" and "hard" nucleophiles with consequently varying abilities to react with particular classes of electrophiles, the major classes of direct-acting mutagens. Although they serve as a first line of defense against mutagens and carcinogens, many interceptor molecules are under-investigated with regard to their spectra of activity and their possible relevance to prophylaxis or treatment of human disease states.

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Protection of Ca++ transport by carnosine against disturbances induced by lipid peroxidation

Cited by 19 publications

References 3 publications

Association between oxidative stress and nutritional status in the elderly

Association between oxidative stress and nutritional status in the elderly

Carnosine attenuates mast cell degranulation and histamine release induced by oxygen–glucose deprivation

Antimutagens and anticarcinogens: A survey of putative interceptor molecules

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