Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes

Bhutada, Pravinkumar; Mundhada, Yogita; Bansod, Kuldeep; Tawari, Santosh; Patil, Shaktipal; Dixit, Pankaj; Umathe, Sudhir N.; Mundhada, Dharmendra

doi:10.1016/j.bbr.2011.01.022

Cited by 180 publications

(108 citation statements)

References 73 publications

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“…These results are quite analogous to those reported by others (Bhutada et al 2011). In comparison to the corresponding values of the diabetic control group, the mean acetylcholinesterase activities in pre-frontal cortex [F(8, 45 analysis).…”

Section: Acetylcholinesterase Enzyme Activitysupporting

confidence: 78%

Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats

Thakur

Rai

Chatterjee³

et al. 2016

Pharmaceutical Biology

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Context Andrographolide containing Andrographis paniculata (Burm. F.) Wall. Ex Nees (Acanthaceae) extracts is often used for treatments of diabetes and other inflammatory disorders commonly accompanying cognitive and other psychiatric disorders.Objective To compare the efficacies of a standardised A. paniculata extract (AP) and pure andrographolide on cognitive functions, oxidative stress and cholinergic function in diabetic rats. Materials and methods Streptozotocin-induced diabetic Charles Foster albino rats treated orally with a hydro-methanolic A. paniculata leaf extract (50, 100 and 200 mg/kg/day), or with pure andrographolide (15, 30 and 60 mg/kg/day) for 10 consecutive days, were subjected to Morris water maze test. After the test, acetylcholinesterase, superoxide dismutase (SOD), and catalase (CAT) activities and lipid peroxidation (LPO) in brain tissues were assessed. Results Acetylcholinesterase activity in pre-frontal cortex and hippocampus of diabetic rats was 2.1 and 2.6 times higher compared to nondiabetic rats. LPO was 1.6 times higher and decreased SOD (56.3%) and CAT (44.9%) activities in pre-frontal cortex of diabetic rats compared to nondiabetic rats. AP or andrographolide treatments dose dependently attenuated cognitive deficits, reduced acetylcholinesterase activity, oxidative stress, improved diabetic hyperglycemia and insulin deficiency. All observed effects of AP were quantitatively almost equal to those expected from its analytically quantified andrographolide content. Discussion and conclusion Reported observations are the very first ones suggesting beneficial effects of andrographolide against diabetes associated cognitive deficits, increased acetylcholinesterase activity and deteriorated antioxidative status. Efforts to exploit A. paniculata extracts enriched in andrographolide as preventive measures against such disorders can be warranted. ARTICLE HISTORY

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Section: Acetylcholinesterase Enzyme Activitysupporting

confidence: 78%

Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats

Thakur

Rai

Chatterjee³

et al. 2016

Pharmaceutical Biology

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“…This finding is consistent with earlier reports in which exposure to neurotoxins resulted in significantly elevated AChE activity [49,50]. Increased AChE activity leads to decrease in acetylcholine levels and cholinergic dysfunctions [51]. In the present study, the activity of AChE was completely normalized among rats supplemented with FO suggesting the benefits of n-3 fatty acids on cholinergic functions.…”

Section: Discussionsupporting

confidence: 83%

Fish Oil Prophylaxis Protects against 3-Nitropropinic Acid-Induced Oxidative Impairments in Striatum and Cerebellum in Male Rat Brain

Kollareth¹,

Babu²,

Bharath³

et al. 2017

Neurochem Neuropharm

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Increasing evidence supports a role for fish oil (FO) and the n-3 polyunsaturated fatty acids (n-3 PUFA) -docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in protecting against neurodegeneration. However, experimental evidence on their neuroprotective efficacy in neurotoxin models is rather limited. In the present study, we examined whether pretreatment with n-3 PUFA in SH-SY5Y cells and FO prophylaxis in rats would render them less susceptible to 3-nitropropionic acid (a mitochondrial toxin, NPA) exposure. Cells pretreated with DHA/EPA were more resistant to NPA-induced perturbations in antioxidant defenses and exhibited higher survival rate. Further, we validated these findings among growing rats provided with FO (4 mL/kg bw) prophylaxis for 4 weeks and subjected to NPA challenge (25 mg/kg bw/d during last 4 d). Interestingly, FO prophylaxis offered significant protection against NPA -induced oxidative dysfunctions and depleted dopamine levels in striatum. Based on our in vitro and in vivo findings, we hypothesize that the protective effect of FO may be wholly or in part related to its potential to enhance GSH, thiols and antioxidant defenses in specific regions of brain of rats. Thus FO prophylaxis is likely to offer a therapeutic advantage as a neuroprotective strategy under oxidative stress-mediated neurodegenerative conditions.

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“…In vitro evaluation of C. mukul gum resin extract revealed that it has a profound effect on the antioxidant defense system (10) and can affect parameters of oxidative stress glutathione and malondialdehyde (GSH and MDA). Commiphora mukul, with profound antioxidant potential and having the ability to trigger cellular antioxidants, can be exploited for its use against a number of disorders including cardiovascular diseases, inflammation, and cancer (17).…”

Section: Discussionmentioning

confidence: 99%

Hydro-alcoholic Extract of Commiphora mukul Gum Resin May Improve Cognitive Impairments in Diabetic Rats

Salehi¹,

Taheraslani²,

Moradkhani³

2015

Avicenna J Med Biochem

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Background: Diabetes causes cognitive impairment. Medicinal plants due to different mechanisms, such as antioxidant activities may improve diabetes and relieve its symptoms. Commiphora mukul (Burseraceae) has a significant antioxidant activity. Objectives: This study aimed to examine the effect of hydro-alcoholic extract of C. mukul on passive-avoidance learning and memory in streptozotocin (STZ) induced diabetic male rats. Materials and Methods: Thirty-two adult male Wistar rats were randomly allocated to four groups: normal, diabetic, normal + extract of C. mukul and diabetic + extract of C. mukul groups with free access to regular rat diet. Diabetes was induced in male rats by single interaperitoneal injection of 60 mg/kg STZ. After the confirmation of diabetes, 300 mg/kg C. mukul extract was orally administered to the extract-treated groups. Control groups received normal saline at the same time. Passive-avoidance memory was tested eight weeks after the STZ treatment, and blood glucose and body weight were measured in all groups at the beginning and end of the experiment. Results: In the present study, diabetes decreased learning and memory. Although the administration of C. mukul extract did not affect the step-through latency (STLa) and the number of trials of the diabetic groups during the first acquisition trial, a significant decrease was observed in STLr and also a significant increase in time spent in the dark compartment (TDC) and number of crossing (NOC) in the retention test (after 24 and 48 hours). Although no significant difference was observed in body weight of diabetic + extract of C. mukul (DE) and diabetic control (DC) groups, the plasma glucose of DE group was significantly lower in comparison to DC group. Conclusions: Commiphora mukul extract can improve passive-avoidance learning and memory impairments in the STZ-induced diabetic rats. This improvement may be due to the antioxidant, acetylcholinesterase inhibitory activity, anti-inflammatory or power to reduce hyperglycemia and lowering cholesterol and triglyceride properties of this extract. The result of this study is a promising point for new therapeutic alternatives in alleviating cognitive impairments caused by diabetes.

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Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes

Cited by 180 publications

References 73 publications

Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats

Beneficial effects of anAndrographis paniculataextract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats

Fish Oil Prophylaxis Protects against 3-Nitropropinic Acid-Induced Oxidative Impairments in Striatum and Cerebellum in Male Rat Brain

Hydro-alcoholic Extract of Commiphora mukul Gum Resin May Improve Cognitive Impairments in Diabetic Rats

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