Protection of goats against peste-des-petits-ruminants with attenuated rinderpest virus

Taylor, W. P.

doi:10.1016/s0034-5288(18)32800-5

Cited by 68 publications

(37 citation statements)

References 10 publications

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“…In the past, when a homologous vaccine against PPR was not available, a heterologous live attenuated tissue culture rinderpest vaccine (TCRP) (based on the antigenic similarity of PPRV with RPV) was used to control PPR [212]. The TCRP vaccine was shown to provide protection against PPR for about one year [10,213]. Later, the use of heterologous PPR vaccine was banned because it might have interfered with the GREP (to achieve status of rinderpest free zone) and to avoid handling of live RPV [11].…”

Section: Disease Controlmentioning

confidence: 99%

See 1 more Smart Citation

Peste Des Petits Ruminants Virus Infection of Small Ruminants: A Comprehensive Review

Kumar

Maherchandani

Kashyap

et al. 2014

Viruses

183

168

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Peste des petits ruminants (PPR) is caused by a Morbillivirus that belongs to the family Paramyxoviridae. PPR is an acute, highly contagious and fatal disease primarily affecting goats and sheep, whereas cattle undergo sub-clinical infection. With morbidity and mortality rates that can be as high as 90%, PPR is classified as an OIE (Office International des Epizooties)-listed disease. Considering the importance of sheep and goats in the livelihood of the poor and marginal farmers in Africa and South Asia, PPR is an important concern for food security and poverty alleviation. PPR virus (PPRV) and rinderpest virus (RPV) are closely related Morbilliviruses. Rinderpest has been globally eradicated by mass vaccination. Though a live attenuated vaccine is available against PPR for immunoprophylaxis, due to its instability in subtropical climate (thermo-sensitivity), unavailability of required doses and insufficient coverage (herd immunity), the disease control program has not been a great success. Further, emerging evidence of poor cross neutralization between vaccine strain and PPRV strains currently circulating in the field has raised concerns about the protective efficacy of the existing PPR vaccines. This review summarizes the recent advancement in PPRV replication, its pathogenesis, immune response to vaccine and disease control. Attempts have also been made to highlight the current trends in understanding the host susceptibility and resistance to PPR.

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Section: Disease Controlmentioning

confidence: 99%

“…Cattle can be infected with PPRV but is unable to transmit the disease to another host, though a sero-conversion against the PPRV H protein has been observed [9]. Antibodies against PPRV in cattle can provide cross protection against RPV [10]. Infection of cattle with PPRV also interferes with immune response against RPV [11].…”

Section: Introductionmentioning

confidence: 99%

Peste Des Petits Ruminants Virus Infection of Small Ruminants: A Comprehensive Review

Kumar

Maherchandani

Kashyap

et al. 2014

Viruses

183

168

View full text Add to dashboard Cite

show abstract

“…Different research groups are focused on developing thermo-resistant live attenuated vaccines to overcome the obstacles posed by having to maintain the cold chain for vaccine distribution [13]. Several strategies that allow the expression of the F and/or H proteins of PPRV using different vectors, including recombinant adenoviral [14], [15] or poxviral vectors [16], [17], and chimeric RPV [18], [19] have been shown to induce long lasting neutralizing antibody responses against PPRV in goats as well as partial or total protection against disease in some cases. Adenoviruses have proved excellent candidates as vaccine delivery vehicles [20], [21] due to their genetic stability, safety [14] and the strong immune response they generate [9], [10], [22], [23], [24].…”

Section: Introductionmentioning

confidence: 99%

Vaccination with Recombinant Adenoviruses Expressing the Peste des Petits Ruminants Virus F or H Proteins Overcomes Viral Immunosuppression and Induces Protective Immunity against PPRV Challenge in Sheep

et al. 2014

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Peste des petits ruminants (PPR) is a highly contagious disease of small ruminants caused by the Morbillivirus peste des petits ruminants virus (PPRV). Two recombinant replication-defective human adenoviruses serotype 5 (Ad5) expressing either the highly immunogenic fusion protein (F) or hemagglutinin protein (H) from PPRV were used to vaccinate sheep by intramuscular inoculation. Both recombinant adenovirus vaccines elicited PPRV-specific B- and T-cell responses. Thus, neutralizing antibodies were detected in sera from immunized sheep. In addition, we detected a significant antigen specific T-cell response in vaccinated sheep against two different PPRV strains, indicating that the vaccine induced heterologous T cell responses. Importantly, no clinical signs and undetectable virus shedding were observed after virulent PPRV challenge in vaccinated sheep. These vaccines also overcame the T cell immunosuppression induced by PPRV in control animals. The results indicate that these adenovirus constructs could be a promising alternative to current vaccine strategies for the development of PPRV DIVA vaccines.

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“…In a country like India where movement of sheep and goats are not subjected to legislative control and slaughter of infected animals is not feasible, the only effective way to control PPR is by vaccination. Attenuated rinderpest vaccine was used successfully as heterologous vaccine to protect against PPR which provided protection for at least one year (Mariner et al 1993;Taylor 1979) in several countries including India as a prophylactic measure but the use of rinderpest vaccine to protect small ruminants against PPR is now contraindicated as its use produces antibodies to rinderpest which compromises serosurveillance for rinderpeast, and thereby the requirements of the global rinderpest eradication programme. A very efficient PPR homologous vaccine was developed with the Nigeria 75/1 strain, isolated in Nigeria in 1975 (Taylor and Abegunda 1975) grown on vero cells which provided a life long immunity.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that vaccination of goats with attenuated rinderpest virus offered protection from PPR virus (Taylor 1979). A heat stable preparation of vero cell adapted RP vaccine was also used against PPR (Mariner et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Standardization of large scale production of homologous live attenuated PPR vaccine in India

Hegde

Gomes

Byregowda

et al. 2007

Trop Anim Health Prod

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Live attenuated homologous vaccine against peste des petits ruminants of sheep and goats was produced on a large scale basis in roller culture bottles using seed virus developed at the Indian Veterinary Research Institute, Muktheswar, India. Vero cells between 130-150 passages with six percent foetal calf serum were used for the production of vaccine. The cells were infected with 0.01 multiplicity of infection and harvested when the cytopathic effect was 80%. The vaccine was freezedried in order to maintain the stability of the vaccine. Identity test and titration was performed and the vaccine titre was monitored to be minimum of 10(5)/100 doses. In-house sterility tests and quality control tests using experimental animals and small ruminants were performed. The vacuum and moisture content of the vaccine were also regulated to be within the normal limits.

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Protection of goats against peste-des-petits-ruminants with attenuated rinderpest virus

Cited by 68 publications

References 10 publications

Peste Des Petits Ruminants Virus Infection of Small Ruminants: A Comprehensive Review

Peste Des Petits Ruminants Virus Infection of Small Ruminants: A Comprehensive Review

Vaccination with Recombinant Adenoviruses Expressing the Peste des Petits Ruminants Virus F or H Proteins Overcomes Viral Immunosuppression and Induces Protective Immunity against PPRV Challenge in Sheep

Standardization of large scale production of homologous live attenuated PPR vaccine in India

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