The relevance of the study is due to the aggravation of changes in external environment that affect economic security of business entities and require the increase in their economic security in the context of globalization challenges and sustainable development. The purpose of the study is to develop principles of assessing adaptive management of economic security of enterprises in the context of globalization challenges and sustainable development. The methodological basis of the research is the structural-functional approach, which makes it possible to consider economic security as a certain system, take into account adaptive behavior of enterprises considering the specifics of their activities, conduct a full and detailed analysis of adaptive management of economic security of enterprises, and ensure the segmentation of economic security by functional areas of its activity, as well as identifying critical security points of the enterprise's functioning. The authors suggested using taxonomic analysis to assess the adaptive management of the enterprises' economic security. The peculiarity of this proposed methodical approach is the establishment of the quality of the influence of analytical features on economic security based on the determination of the Euclidean distance between the standardized values of analytical features and the value of the reference vector and the calculation of the integral indicator of the assessment of the adaptive management of the enterprise' economic security. Approbation of the proposed approach was in relation to the functioning enterprise on the territory of Ukraine, Eurotrading LLC, which carries out production activities. The calculations and taxonomic analysis were based on the actual values of the analytical assessment of the financial, intellectual, personnel and production components of the enterprise's economic security for five years. The results of the application of the proposed methodological approach made it possible to determine the largest root mean square deviation of analytical features, including the duration of accounts payable turnover and the turnover ratio of fixed assets. This made it possible to propose directions of adaptive management to increase the enterprise' economic security in the context of globalization challenges and sustainable development.