Protection of Marrow from Methotrexate Toxicity by Gene Transfer of Mutant Forms of Dihydrofolate Reductase into Hematopoietic Progenitor Cells

Bertino, Joseph R.; Banerjee, D.; Zhao, Shi Cheng; Mineishi, Shin; Ercikan-Abali, Emine A.; Takebe, Naoko; Sadelain, Michel; Moore, Malcolm A.S.

doi:10.1007/978-3-642-71960-8_63

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2003

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“…Leflunomide's clinical efficacy rivals that of methotrexate and salazopyrene yet elicits a faster onset of response. 10 Furthermore, unlike methotrexate, 11,12 leflunomide does not result in bone marrow toxicity. 2,4 The adverse effects of leflunomide have been summarized as mild to moderate and can be easily resolved.…”

Section: Introductionmentioning

confidence: 96%

A convenient synthesis of ¹³C₄‐Leflunomide and its primary metabolite ¹³C₄‐A77 1726

Faragher

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Kaminski³

et al. 2003

Labelled Comp Radiopharmac

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SummaryA convenient synthesis of leflunomide and its primary pharmacologically active metabolite A77 1726, each labeled with four 13 C atoms has been achieved. Starting from 13 C 4 -ethyl acetoacetate, each step of the synthesis proceeds in 60-82% yield. Analysis of the mass spectra of the labeled and unlabeled materials demonstrates that the compounds prepared herein will be suitable as analytical standards for bioavailability studies.

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Section: Introductionmentioning

confidence: 96%

A convenient synthesis of ¹³C₄‐Leflunomide and its primary metabolite ¹³C₄‐A77 1726

Faragher

Motto

Kaminski³

et al. 2003

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

show abstract

Protection of Marrow from Methotrexate Toxicity by Gene Transfer of Mutant Forms of Dihydrofolate Reductase into Hematopoietic Progenitor Cells

Cited by 1 publication

References 19 publications

A convenient synthesis of ¹³C₄‐Leflunomide and its primary metabolite ¹³C₄‐A77 1726

A convenient synthesis of ¹³C₄‐Leflunomide and its primary metabolite ¹³C₄‐A77 1726

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Protection of Marrow from Methotrexate Toxicity by Gene Transfer of Mutant Forms of Dihydrofolate Reductase into Hematopoietic Progenitor Cells

Cited by 1 publication

References 19 publications

A convenient synthesis of 13C4‐Leflunomide and its primary metabolite 13C4‐A77 1726

A convenient synthesis of 13C4‐Leflunomide and its primary metabolite 13C4‐A77 1726

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A convenient synthesis of ¹³C₄‐Leflunomide and its primary metabolite ¹³C₄‐A77 1726

A convenient synthesis of ¹³C₄‐Leflunomide and its primary metabolite ¹³C₄‐A77 1726