Protection of Mice Against Vaccinia Virus by Administration of Benzaldehyde Thiosemicarbazone.

Columbia SK Group of Viruses

“…Introduction of the phenyl, 4-hydroxyphenyl, n-hexyl, styryl and 3-methoxy-4-hydroxyphenyl groups at this point yielded active compounds whereas a nurober of other related or unrelated substituents were inactive. A complex pyrimidine, i. e. 5-(2: 4-dichlorophenoxy)-4-hydroxy-2-mercaptopyrimidine, which produced some favorable effects against vaccinia infection, had no action on Col SK virus infection in mice (THOMPSON et al 1951). A similar relation between chemical structure of purine antagonists and antiviral properlies against poliomyelitis virus has been described by BROWN (1952), BROWN and AcKERMAN (1951) and by AINSLIE (1952).…”

The Thiosemicarbazones

“…24 ( Fig. 1) to confirm the sparing ability of this series of compounds in vaccinia-infected mice, THOMPSON et al (1951) found that there was slightly more inactivation of extracellular virus in the presence than in the absence of the compound. The same result was obtained with the p-acetamido analog, but in both cases the authors appeared to consider the differences insignificant.…”

Studies of Some Substances with Antiviral Activity

“…It was established that the related compounds-thiosemicarbazones-are effective especially against poxviruses as determined in laboratory experiments as well as in some cases by clinical trials (Hamre et al, 1951;Thompson et al, 1951;Bauer, 1955;Bauer and Sadler, 1960;Bauer el al., 1963;Slack el al., 1964;O'Sullivan et al, 1964;Appleyard et al, 1965). An inhibitory action was also reported on the PR 8 strain of influenza A virus (Lum and Smith, 1957) and a slight effect against Rift valley fever virus (Bauer, 1955).…”