Protection of outer hair cells from reperfusion injury by an iron chelator and a nitric oxide synthase inhibitor in the guinea pig cochlea

Tabuchi, Keiji; Okubo, Hideki; Fujihira, Kazuya; Tsuji, Shigeki; Hara, Akira; Kusakari, Jun

doi:10.1016/s0304-3940(01)01919-x

Cited by 18 publications

(20 citation statements)

References 14 publications

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“…Auditory vascular perfusion may become limited in certain conditions requiring flexibility of blood vessels to provide adequate blood flow. Tabuchi et al (2001) have reported that following in vitro ischemia in the guinea pig cochlea, DPOAE amplitudes decreased. When reperfused, the DPOAEs had a shortlived recovery with subsequent decrease in amplitude after 20 min.…”

Section: Microangiopathymentioning

confidence: 99%

Characterization of hearing loss in aged type II diabetics

et al. 2006

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Presbycusis - age-related hearing loss - is the number one communicative disorder and a significant chronic medical condition of the aged. Little is known about how type II diabetes, another prevalent age-related medical condition, and presbycusis interact. The present investigation aimed to comprehensively characterize the nature of hearing impairment in aged type II diabetics. Hearing tests measuring both peripheral (cochlea) and central (brainstem and cortex) auditory processing were utilized. The majority of differences between the hearing abilities of the aged diabetics and their age-matched controls were found in measures of inner ear function. For example, large differences were found in pure-tone audiograms, wideband noise and speech reception thresholds, and otoacoustic emissions. The greatest deficits tended to be at low frequencies. In addition, there was a strong tendency for diabetes to affect the right ear more than the left. One possible interpretation is that as one develops presbycusis, the right ear advantage is lost, and this decline is accelerated by diabetes. In contrast, auditory processing tests that measure both peripheral and central processing showed fewer declines between the elderly diabetics and the control group. Consequences of elevated blood sugar levels as possible underlying physiological mechanisms for the hearing loss are discussed.

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Section: Microangiopathymentioning

confidence: 99%

Characterization of hearing loss in aged type II diabetics

et al. 2006

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“…Distortion-product otoacoustic emissions (DPOAE) were reported to be a rapid responding method in correlation with CBF changes that can be used as a cochlear monitoring tool, but were difficult to acquire intraoperatively due to their high sensitivity to acoustic noise (Telischi et al, 1996;Mom et al, 1999). Endocochlear potentials (EPs) were also used in animals to monitor cochlear function, but such measurements are highly invasive prohibiting clinical usage (Tabuchi et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

Simultaneous measurement of electrocochleography and cochlear blood flow during cochlear hypoxia in rabbits

Yavuz¹,

Morawski²,

Telischi³

et al. 2005

Journal of Neuroscience Methods

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In this study, a new monitoring system is developed to measure cochlear blood flow (CBF) and electrocochleography (ECochG) during transient ischemic episodes of the cochlea. A newly designed otic probe was used for the simultaneous recordings of laser-Doppler CBF and ECochG directly from the round window (RW). The probe enabled the recording of high amplitude compound action potentials (CAP) and cochlear microphonics (CM) with few averages. Experiments were conducted on rabbits to generate episodes of cochlear ischemia by using timed compressions of the internal auditory artery (IAA). The computer monitoring system extracted and measured CAP and CM components from ECochG in real-time. Results indicate that CM and CAP generally followed CBF during compressions and releases of IAA. Both CBF values and CAP amplitudes showed an overshoot following the reperfusion. CAP amplitude measures were found to be very sensitive to ischemia showing very rapid amplitude, latency and morphological changes. CM amplitude decreased more slowly than the CAP and CBF. Simultaneous recordings of CBF and ECochG using the otic probe provide a valuable neuromonitoring tool to investigate the dynamic behavior of the cochlea during ischemia.

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“…Because our recording methods for DPOAEs have been described elsewhere (9), only a brief summary will be given here. Two primary tones were delivered to the emitters contained within a custom-made ear probe.…”

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confidence: 99%

Dehydroepiandrosterone Sulfate Reduces Acoustic Injury of the Guinea-Pig Cochlea

et al. 2005

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Abstract. The present study was performed to determine effects of dehydroepiandrosterone sulfate (DHEAS), a neurosteroid, on acoustic injury. Albino guinea pigs were exposed to a 2 kHz pure tone of 120 or 125 dB sound pressure level for 10 min immediately after intravenous administration of DHEAS. Statistically significant improvement in the compound action potential threshold shifts and in amplitude reduction of distortion-product otoacoustic emissions was observed 1 week after the acoustic overexposure in the animals treated with DHEAS. The present results suggest that DHEAS has a protective effect against acoustic injury of the cochlea.

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Protection of outer hair cells from reperfusion injury by an iron chelator and a nitric oxide synthase inhibitor in the guinea pig cochlea

Cited by 18 publications

References 14 publications

Characterization of hearing loss in aged type II diabetics

Characterization of hearing loss in aged type II diabetics

Simultaneous measurement of electrocochleography and cochlear blood flow during cochlear hypoxia in rabbits

Dehydroepiandrosterone Sulfate Reduces Acoustic Injury of the Guinea-Pig Cochlea

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