Protection of the mouse from genetic radiation damage by an optimal-dose-ratio combination of ATP, AET, and serotonin

Abstract

The study concerned antiradiation effects in germ-cell genetic structures produced by a combination of ATP, AET, and serotonin at dose ratio optimal for lethality namely, 45:3:1, as arrived at in our previous work. Such a combination was found to reduce by a factor of 2 the translocation yields observed after 400 R X-rays to mouse spermatogonia. In terms of animal survival, ATP has been shown to contribute little to total protection achieved by the same combination; in terms of genetic damage; however, the role of ATP proved essential. Removal of ATP from the combination led to a significant reduction in protective effect.

The Relation of ATP Response in CaNT Tumours after X-Irradiation to Varying Tumour Volumes

“…Less than 1 % of the activity was measured in 7 of the 10 clamped tumours tested, which was interpreted as evidence that the occlusion of the blood vessels was effective. ATP has been shown to modify the response to radiation in several situations [12][13][14], But this response following ionising radiation is dependent upon adequate cellular supply, availability and utilisation of energy. Nagle et al [5] demonstrated that V79 Chinese hamster cells depleted in ATP were unable to rejoin X-ray-induced DNA strand breaks.…”