Protective Action of Anoxic Anoxia Against Total Body Roentgen Irradiation of Mammals

Dowdy, Andrew H.; Bennett, Leslie R.; Chastain, Sarah M.

doi:10.1148/55.6.879

Cited by 96 publications

(23 citation statements)

References 4 publications

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“…On the other hand in anoxic animals breathing 92 per cent nitrogen and 8 per cent oyxgen little tumor regression was observed. This agrees with findings of Dowdy et al (66) that anoxia protects animals from irradiation death.…”

Section: Recent Investigations By Hollcroft and Matthewssupporting

confidence: 94%

Radioactivity Biologic Effects of Ionizing Radiations

Lorenz¹,

Congdon²

1954

Annu. Rev. Med.

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Section: Recent Investigations By Hollcroft and Matthewssupporting

confidence: 94%

Radioactivity Biologic Effects of Ionizing Radiations

Lorenz¹,

Congdon²

1954

Annu. Rev. Med.

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“…It has been shown that, for protection of mammals against lethal doses of radiation, a critical level of hypoxia (5% O 2 or less), is as effective as some most efficacious chemical protective agents [5]. Moderate 10% O 2 hypoxia was shown to decrease lethal effects of X and gamma irradiation [3,9,18,19] and to protect intestinal as well as hemopoietic tissue. Strain and species differences in radioprotection with 10% O 2 were observed [17].…”

Section: Introductionmentioning

confidence: 99%

Modulation of Radioprotective Effects of Respiratory Hypoxia by Changing the Duration of Hypoxia before Irradiation and by Combining Hypoxia and Administration of Hemopoiesis-Stimulating Agents

2001

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“…The increase of radioresistance of animals breathed by gaseous hypoxic mixture (GHM) during irradiation was first of all obtained by Dowdy et al (1950). …”

Section: Reviewmentioning

confidence: 88%

Comments on the mechanisms of action of radiation protective agents: basis components and their polyvalence

Vasin

2014

SpringerPlus

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PurposeThese comments suggest a division of radiation protective agents on the grounds of their mechanism of action that increase the radio resistance of an organism.ConclusionGiven below is the division of radiation protective agents on the basis of their mechanism of action into 3 groups: 1) Radiation protective agents, with the implementation of radiation protective action taking place at the cellular level in the course of rapidly proceeding radiation-chemical reactions. At the same time, when the ionizing radiation energy is absorbed, these agents partially neutralize the “oxygen effect” as a radiobiological phenomenon, especially in the radiolysis of DNA; 2) Radiation protective agents that exert their effect at the system level by accelerating the post-radiation recovery of radiosensitive tissues through activation of a number of pro-inflammatory signaling pathways and an increase in the secretion of hematopoietic growth factors, including their use as mitigators in the early period after irradiation prior to the clinical development of acute radiation syndrome (ARS). 3) Radiomodulators including drugs and nutritional supplements that can elevate the resistance of the organism to adverse environmental factors, including exposure to ionization by means of modulating the gene expression through a hormetic effect of small doses of stressors and a “substrate” maintenance of adaptive changes, resulting in an increased antioxidant protection of the organism. Radiation protective agents having polyvalence in implementation of their action may simultaneously induce radioprotective effect by various routes with a prevalence of basis mechanisms of the action.

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Protective Action of Anoxic Anoxia Against Total Body Roentgen Irradiation of Mammals

Cited by 96 publications

References 4 publications

Radioactivity Biologic Effects of Ionizing Radiations

Radioactivity Biologic Effects of Ionizing Radiations

Modulation of Radioprotective Effects of Respiratory Hypoxia by Changing the Duration of Hypoxia before Irradiation and by Combining Hypoxia and Administration of Hemopoiesis-Stimulating Agents

Comments on the mechanisms of action of radiation protective agents: basis components and their polyvalence

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