Protective Action of D-Ribose against Renal Injury Caused by Ischemia and Reperfusion in Rats with Transient Hyperglycemia

Modulation of intracellular ATP determines adenosine release and functional outcome in response to metabolic stress in rat hippocampal slices and cerebellar granule cells

“…Indeed, the positive effects of Rib or Rib and Ade on the recovery of post-ischaemic myocardial ATP and TAN in in vitro and in vivo preparations are well documented (Zimmer 1982(Zimmer , 1996Mauser et al 1985;St Cyr et al 1986;Zimmer et al 1989;Muller et al 1998;Smolenski et al 1998;Perkowski et al 2007). Furthermore, improved postischaemic ATP recovery has been linked to an enhanced functional recovery of the heart, as seen in improved cardiac contractility (Pasque and Wechsler 1984;Lamberts et al 2007;Schneider et al 2008), and may also provide benefit in renal ischaemic injury (Nishiyama et al 2009;Sato et al 2009). In humans, administration of Rib to patients suffering from congestive heart failure (Pliml et al 1992;Omran et al 2003Omran et al , 2004MacCarter et al 2009) has been shown to have beneficial effects on cardiac function, likely via improved cardiac energy metabolism, which has led to suggestions that Rib should be used therapeutically (Pauly and Pepine 2000;Shecterle et al 2010).…”

D-Ribose Ameliorates Cisplatin-Induced Nephrotoxicity by Inhibiting Renal Inflammation in Mice

“…Among familiar monosaccharides, D-ribose is a naturally occurring five-carbon monosaccharide that is found in all living cells. D-ribose not only has potential as a metabolic supplement for the heart (Pauly and Pepine 2000), but also exerts anti-inflammatory effects against conditions such as renal ischemia/reperfusion injury (Nishiyama et al 2009;Sato et al 2009). In this study, the inhibitory effect of activation of TNF-α with D-ribose on cisplatin-induced nephrotoxicity is almost same potency compared with that of D-allose (Miyawaki et al 2012).…”

“…It is the sugar moiety of adenosine triphosphate (ATP), therefore, it has been investigated as a potential metabolic supplement for the heart (Pauly and Pepine 2000). We have previously demonstrated that D-ribose has anti-inflammatory effects in renal ischemia/reperfusion injury (Nishiyama et al 2009;Sato et al 2009). These antiinflammatory effects have suggested new approaches to development of renoprotective strategies for use during cisplatin chemotherapy.…”

Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia

“…Recently, even transient hyperglycemic episodes during IR in nondiabetic animals have been reported to significantly intensify renal injury through various mechanisms including ROS production and activation of systemic inflammatory reactions [7,8]. Indeed, hyperglycemia has been shown to mitigate the protective effect of volatile anesthetics against IR injury [18].…”

“…Acute and chronic hyperglycemia are associated with impaired nitric oxide (NO) availability [5] and excessive ROS production during IR [6]. In conjunction, recent studies have depicted that even transient hyperglycemic episodes during IR in nondiabetic animals significantly intensifies renal injury through increased ROS and proinflammatory cytokines production and neutrophil activation and infiltration [7,8]. Accounting for the frequent encounter of hyperglycemia in the surgical theatre and its potential to aggravate renal IR injury, studies addressing effective protective strategies seem mandatory.…”