Protective action of glutamate antibodies on increased expression of genes of programmed death of rat brain cells induced by injection of a β-amyloid fragment (25–35)

Kolobov, V. V.; Давыдова, Т. В.; Фомина, В. Г.

doi:10.1134/s1062359014020034

Cited by 3 publications

(2 citation statements)

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“…AT-Glu had a protective effect on mnestic functions of animals with age-related changes. This effect seems to be associated with the influence of AT-Glu on neuronal apoptosis [4,5]. AT-Glu administration did not change horizontal or vertical motor activity in the open field, however, in the case of AT-Glu administration, decreased speed of movement was observed.…”

Section: Resultsmentioning

confidence: 79%

Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice

et al. 2019

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Chronic intranasal administration of antibodies to glutamate to aging C57Bl/6 mice improved passive avoidance conditioning, had no effect on horizontal and vertical locomotor activity, but slowed locomotion in the open-field test. Administration of antibodies to glutamate increased the content of dopamine and its metabolites in mouse hippocampus, but had no effect on the metabolism of neurotransmitter amino acids. In the frontal cortex, antibodies to glutamate did not affect neurotransmitter metabolism, but increased the level of both excitatory and inhibitory amino acids without changing their ratio.

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Section: Resultsmentioning

confidence: 79%

Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice

et al. 2019

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“…This action potentially stems from the development of glutamate excitotoxicity and subsequent apoptotic neuronal death in relevant brain structures. Hence, intranasal co-administration of AB-GL with S100A9 fibrils reversed the passive avoidance behavioral disruption through a protective antiamnestic action probably originating from AB-GL binding any glutamate excess thereby reducing the prospect of neuronal apoptosis [8,9]. The marked increase in horizontal locomotor activity in the open field following co-administration of AB-GL with S100A9 fibrils reflected unhindered orienting-exploratory activity.…”

Section: Resultsmentioning

confidence: 94%