Protective Action of L. salivarius SGL03 and Lactoferrin against COVID-19 Infections in Human Nasopharynx

Kucia, Marzena; Wietrak, Ewa; Szymczak, Mateusz; Majchrzak, Michał; Kowalczyk, Paweł

doi:10.3390/ma14113086

Cited by 3 publications

(2 citation statements)

References 120 publications

(253 reference statements)

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“…Breastmilk can inhibit the activity of the SARS-CoV-2. Moreover, drugs ( 53 , 75 , 76 ) and microorganisms ( 77 , 78 ) combined with LF can better inhibit the activity of SARS-CoV-2. In the future, the effect of other drugs which are capable of inhibiting SARS-CoV-2, such as artemether ( 110 ), artesunate ( 110 ), cepharanthine ( 111 ), and molnupiravir ( 112 , 113 ), combined with human milk ingredients against SARS-CoV-2 can also be further investigated.…”

Section: Discussionmentioning

confidence: 99%

“…The combination of LF and drugs, such as remdesivir ( 53 ), hydroxychloroquine ( 75 ), and hypothiocyanite ( 76 ), can enhance the antiviral activity against SARS-CoV-2. Lacticaseibacillus paracasei DG ( 77 ) and LigiLactobacillus Salivarius SGL03 ( 78 ) can also enhance the antiviral activity against SARS-CoV-2 of LF.…”

Section: Sars-cov-2 Rna Positive In Breastmilk But Without Infectious...mentioning

confidence: 99%

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Overview of Breastfeeding Under COVID-19 Pandemic

Pang

Tian

et al. 2022

Front. Immunol.

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During the global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), pregnant and lactating women are at higher risk of infection. The potential of viral intrauterine transmission and vertical transmission by breastfeeding has raised wide concerns. Breastmilk is rich in nutrients that contribute to infant growth and development, and reduce the incidence rate of infant illness and death, as well as inhibit pathogens significantly, and protect infants from infection. Although it is controversial whether mothers infected with COVID-19 should continue to breastfeed, many countries and international organizations have provided recommendations and guidance for breastfeeding. This review presents the risks and benefits of breastfeeding for mothers infected with COVID-19, and the reasons for the absence of SARS-CoV-2 active virus in human milk. In addition, the antiviral mechanisms of nutrients in breastmilk, the levels of SARS-CoV-2 specific antibodies in breastmilk from COVID-19 infected mothers and vaccinated mothers are also summarized and discussed, aiming to provide some support and recommendations for both lactating mothers and infants to better deal with the COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 99%

Section: Sars-cov-2 Rna Positive In Breastmilk But Without Infectious...mentioning

confidence: 99%

Overview of Breastfeeding Under COVID-19 Pandemic

Pang

Tian

et al. 2022

Front. Immunol.

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The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

Kell

2022

Biochemical Journal

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Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced during the reoxygenation phase following hypoxia, is well known in a variety of acute circumstances. We argue here that I–R injury also underpins elements of the pathology of a variety of chronic, inflammatory diseases, including rheumatoid arthritis, ME/CFS and, our chief focus and most proximally, Long COVID. Ischaemia may be initiated via fibrin amyloid microclot blockage of capillaries, for instance as exercise is started; reperfusion is a necessary corollary when it finishes. We rehearse the mechanistic evidence for these occurrences here, in terms of their manifestation as oxidative stress, hyperinflammation, mast cell activation, the production of marker metabolites and related activities. Such microclot-based phenomena can explain both the breathlessness/fatigue and the post-exertional malaise that may be observed in these conditions, as well as many other observables. The recognition of these processes implies, mechanistically, that therapeutic benefit is potentially to be had from antioxidants, from anti-inflammatories, from iron chelators, and via suitable, safe fibrinolytics, and/or anti-clotting agents. We review the considerable existing evidence that is consistent with this, and with the biochemical mechanisms involved.

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Can Lactoferrin, a Natural Mammalian Milk Protein, Assist in the Battle against COVID-19?

Einerhand¹,

Loo-Bouwman

Weiss

et al. 2022

Nutrients

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Notwithstanding mass vaccination against specific SARS-CoV-2 variants, there is still a demand for complementary nutritional intervention strategies to fight COVID-19. The bovine milk protein lactoferrin (LF) has attracted interest of nutraceutical, food and dairy industries for its numerous properties—ranging from anti-viral and anti-microbial to immunological—making it a potential functional ingredient in a wide variety of food applications to maintain health. Importantly, bovine LF was found to exert anti-viral activities against several types of viruses, including certain SARS-CoV-2 variants. LF’s potential effect on COVID-19 patients has seen a rapid increase of in vitro and in vivo studies published, resulting in a model on how LF might play a role during different phases of SARS-CoV-2 infection. Aim of this narrative review is two-fold: (1) to highlight the most relevant findings concerning LF’s anti-viral, anti-microbial, iron-binding, immunomodulatory, microbiota-modulatory and intestinal barrier properties that support health of the two most affected organs in COVID-19 patients (lungs and gut), and (2) to explore the possible underlying mechanisms governing its mode of action. Thanks to its potential effects on health, bovine LF can be considered a good candidate for nutritional interventions counteracting SARS-CoV-2 infection and related COVID-19 pathogenesis.

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Protective Action of L. salivarius SGL03 and Lactoferrin against COVID-19 Infections in Human Nasopharynx

Cited by 3 publications

References 120 publications

Overview of Breastfeeding Under COVID-19 Pandemic

Overview of Breastfeeding Under COVID-19 Pandemic

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

Can Lactoferrin, a Natural Mammalian Milk Protein, Assist in the Battle against COVID-19?

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