Protective action of melatonin on diabetic rat testis at cellular, hormonal and immunohistochemical levels

A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies

“…According to the results, although DM did not meaningfully affect testes’ weights in most reports ( 3 , 31 , 35 , 37 ), it significantly reduced testis weights in two studies ( 3 , 32 ). Treatment with melatonin increased testes weight in a study ( 36 ). Evaluation of the results showed that DM significantly increased the levels of thiobarbituric acid reactive substances (TBARs), malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), as well as (glutathione-S-transferase) GST activity, reduced glutathione (GSH) levels, and catalase (CAT) activity, and caused an imbalance (elevation or reduction) in superoxide dismutase (SOD) activity ( 33 , 35 – 37 ).…”

“…Evaluation of the results showed that DM significantly increased the levels of thiobarbituric acid reactive substances (TBARs), malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), as well as (glutathione-S-transferase) GST activity, reduced glutathione (GSH) levels, and catalase (CAT) activity, and caused an imbalance (elevation or reduction) in superoxide dismutase (SOD) activity ( 33 , 35 – 37 ). In comparison, melatonin treatment could balance the parameters mentioned above in diabetic subjects ( 33 , 35 , 36 ). DM-induced hyperglycemia significantly up-regulated 78-KD glucose-regulated protein (Grp78), C/EBP homologous protein (CHOP), caspase-12, P53, and caspase-3 genes, increased protein expressions of Grp78, CHOP, apoptotic proteins such as P53 and caspase-3, elevated tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) also reduced ratio of Bcl-2/Bax.…”

A Review of foods and food supplements increasing testosterone levels

“…Melatonin is a hormone present in animals, plants, and microorganisms and is also used as a supplement. Melatonin increases testosterone levels in various animal species [103][104][105][106][107][108]. Melatonin suppresses the decrease in testosterone levels due to testicular toxicity [109][110][111][112].…”

Técnicas De Análise Espacial Aplicadas Na Atenção Primária Em Saúde Em Fortaleza No Ceará: Estudo De Caso Da Dengue No Contexto Sócio Sanitário Da Pandemia Da Covid-19 Na Uaps Maurício Mattos Dourado

“…A melatonina exerce um papel importante como antioxidante, estimulando as defesas oxidativas e atuando como sequestradora de radicais livres (ALVES et al, 2020). Além disso, o hormônio é modulador de atividades metabólicas, reprodutivas e imunológicas, especialmente por sua ação anti inflamatória (FAVERO et al, 2017).…”

“…Essas moléculas promovem danos a diversas estruturas como proteínas e lípidos e ainda promovem a mobilização de citocinas pró inflamatórias, podendo levar a morte celular, necrose e perca ou declínio da função do órgão(GOULART, 2015; ZHU, 2019).Tratamento com antioxidantes tem demonstrado efeitos protetores e reversivos causados pelo alcoolismo nos diferentes órgãos(AL-QURAISHY, 2017;BJØRKHAUG, 2020;CANTACORPS, 2020; WANG, 2020). A melatonina é o principal hormônio da glândula pineal (TAMURA, 2014), ela atua principalmente no controle do ciclo circadiano, mas também tem papel em diversos sistemas orgânicos, possuindo alto poder antioxidante(LEIBOWITZ, 2008;NDUHIRABANDI, 2011;RAHMAN, 2017;ALVES, 2020) . motora de filhotes de mães que consumiram álcool durante a gestação e tratadas com melatonina foi significantemente maior que a dos filhotes que nascidos de mães sem tratamento nos estudosde Bagheri et al (2015).…”