Protective Action of Sodium Tetraborate on Chrom-Induced Hepato- and Genotoxicity in Rats

Maratovich, Iztleuov Yerbolat; Narimanovna, Kubenova Nurgul; Vladimirovna, Ismailova Irina; Kapenovich, Iztleuov Marat

doi:10.13005/bpj/1226

Cited by 8 publications

(2 citation statements)

References 33 publications

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“…Unlike GSH, borax can provide a potential substitute when an antioxidant is utilized in aminesensitive environments. Specifically, borax exhibits antioxidant properties in radical-rich environments due to its affinity for hydroxyl groups and its ability to form diester bridges between cis-hydroxyl-containing molecules [36]. Comparatively, GSH involves the sulfhydryl group of the cysteine interacting with radicals [37].…”

Section: Discussionmentioning

confidence: 99%

Strategies to prevent dopamine oxidation and related cytotoxicity using various antioxidants and nitrogenation

et al. 2019

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Dopamine (DA) plays several important roles in the brain and body and has recently been used as a bioadhesive precursor for medical applications. However, DA oxidizes immediately when exposed to oxygen and rapidly polymerizes into polydopamine (PDA), leading to oxidative stress, cytotoxicity, and loss of DA functionalities. As a result, preventing rapid oxidation of DA is of paramount importance but still remains a major challenge. Here, we report several strategies to impede DA oxidation in relevant aqueous solutions (i.e., water, PBS, and cell culture media). One strategy is based on using reducing agents or antioxidants such as glutathione in its reduced state (GSH) and sodium tetraborate (commonly known as borax). Another strategy is based on nitrogenation, a method used to preserve DA in its reduced form by creating an oxygen-free environment. Our data suggest that the antioxidant properties of GSH and borax substantially decreased DA oxidation for up to 2 months. Nitrogenation or oxygen removal further prevented DA oxidation, enhancing its shelf life for longer periods of time. When tested with mammalian cells, preventing DA oxidation with GSH dramatically improved viability of 3T3 fibroblasts and T cells. These results demonstrate that the use of antioxidants, alone or in combination with nitrogenation, can help prevent DA oxidation and improve its stability for cell-based studies or for the design and development of biomaterials.

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Section: Discussionmentioning

confidence: 99%

Strategies to prevent dopamine oxidation and related cytotoxicity using various antioxidants and nitrogenation

et al. 2019

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“…Twenty-four rats were divided into four groups ( n = 6 each): Control (0.5 mL, i.p. isotonic solution), Pb (50 mg/kg/day i.p., Merck, USA), 45 Na 2 B 4 O 7 (4.0 mg/kg/day oral) (Sigma, USA), 46 and Pb + Na 2 B 4 O 7 . After the fifth day, anesthesia was induced in the rats using 60 mg/kg i.p.…”

Section: Methodsmentioning

confidence: 99%

The Effects of Sodium Tetraborate against Lead Toxicity in Rats: The Behavior of Some Metabolic Enzymes

et al. 2023

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This study was planned to research the in vivo effects of lead (Pb) ions and sodium tetraborate (Na 2 B 4 O 7 ) on G6PD and 6PGD, which are some of the enzymes of the pentose phosphate pathway, which carries vital importance for metabolism, and GR and GST, which are glutathione metabolism enzymes, and the in vitro effects of the same agents on the 6PGD enzyme. According to the in vivo analysis results, in comparison to the control group, the rat liver G6PD (p < 0.05), and 6PGD (p < 0.01) enzyme activities in the Na 2 B 4 O 7 group were significantly lower. In addition, GR and GST enzyme activities were insignificantly lower in the Na 2 B 4 O 7 group compared to the control group (p > 0.05). The Pb group had lower G6PD and 6PGD enzyme activity levels and higher GR and GST enzyme activity levels compared to the control group, while these changes did not reach statistical significance (p > 0.05). In the in vitro analyses of the effects of Pb ions on the 6PGD enzyme that was purified out of rat liver with the 2′,5′-ADP-Sepharose 4B affinity chromatography method, it was determined that Pb ions (200−1200 μM) increased the rat liver 6PGD enzyme activity levels by 33%. On the other hand Na 2 B 4 O 7 was not significantly effective on 6PGD activity. These results will also contribute to future studies in understanding the physiopathology of the states triggered by Pb ions and sodium tetraborate (Na 2 B 4 O 7 ).

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Biochemical and histomorphological findings in Swiss Wistar rats treated with potential boron-containing therapeutic - K2[B3O3F4OH]

Haverić

Durmić-Pašić

Alić

et al. 2020

Journal of Trace Elements in Medicine and Biology

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Protective Action of Sodium Tetraborate on Chrom-Induced Hepato- and Genotoxicity in Rats

Cited by 8 publications

References 33 publications

Strategies to prevent dopamine oxidation and related cytotoxicity using various antioxidants and nitrogenation

Strategies to prevent dopamine oxidation and related cytotoxicity using various antioxidants and nitrogenation

The Effects of Sodium Tetraborate against Lead Toxicity in Rats: The Behavior of Some Metabolic Enzymes

Biochemical and histomorphological findings in Swiss Wistar rats treated with potential boron-containing therapeutic - K2[B3O3F4OH]

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