Protective actions of microbiota intervention in two animal models of osteoarthritis: complementary approaches in spontaneous osteoarthritis in Dunkin Hartley Guinea pigs and surgically induced in rabbit

Abstract

Figure 1. Lactate dehydrogenase (LDH) release 24 h post-treatment with LU (treated) or no treatment (control). The result suggests that viability of chondrocytes was not affected by LU exposure.

Osteoarthritis in pet guinea pigs: an update on diagnosis, treatment and management

“…Guinea pigs have been used as an animal model of osteoarthritis investigating the protective actions of microbiota and vitamin C in preventing development of osteoarthritis lesions. Lyophilized inactivated culture and lipoprotein extract of Bifidobacterium longum were used with or without Vitamin C supplements and were found to act against dysbiosis during disease development, with vitamin C enhancing the effect (Henrotin et al, 2017).…”