Protective Actions of Oral Administration of <i>Bifidobacterium longum</i> CBi0703 in Spontaneous Osteoarthritis in Dunkin Hartley Guinea Pig Model

Henrotin, Yves; Patrier, Stéphane; Pralus, Amandine; Roche, M; Nivoliez, Adrien

doi:10.1177/1947603519841674

Cited by 33 publications

(21 citation statements)

References 39 publications

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“…Each title and abstract was reviewed, and 1,434 records were excluded. Upon detailed review of full text, an additional 12 studies were excluded: three lacked the analysis on BMD; 21 - 23 five were performed to study the role of GM on rheumatoid arthritis and osteoarthritis; 24 - 28 three were unrelated to gut-bone axis; 29 - 31 and one concerned bone marrow transplantation. 32 A total of 30 studies were included for our systematic review, which were published from 2012 to 2020 (Supplementary Table i and Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

The role of gut microbiota in bone homeostasis

Liu

et al. 2021

Bone & Joint Research

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Aims The effect of the gut microbiota (GM) and its metabolite on bone health is termed the gut-bone axis. Multiple studies have elucidated the mechanisms but findings vary greatly. A systematic review was performed to analyze current animal models and explore the effect of GM on bone. Methods Literature search was performed on PubMed and Embase databases. Information on the types and strains of animals, induction of osteoporosis, intervention strategies, determination of GM, assessment on bone mineral density (BMD) and bone quality, and key findings were extracted. Results A total of 30 studies were included, of which six studies used rats and 24 studies used mice. Osteoporosis or bone loss was induced in 14 studies. Interventions included ten with probiotics, three with prebiotics, nine with antibiotics, two with short-chain fatty acid (SCFA), six with vitamins and proteins, two with traditional Chinese medicine (TCM), and one with neuropeptide Y1R antagonist. In general, probiotics, prebiotics, nutritional interventions, and TCM were found to reverse the GM dysbiosis and rescue bone loss. Conclusion Despite the positive therapeutic effect of probiotics, prebiotics, and nutritional or pharmaceutical interventions on osteoporosis, there is still a critical knowledge gap regarding the role of GM in rescuing bone loss and its related pathways. Cite this article: Bone Joint Res 2021;10(1):51–59.

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Section: Resultsmentioning

confidence: 99%

The role of gut microbiota in bone homeostasis

Liu

et al. 2021

Bone & Joint Research

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“…Obesity-induced synovial inflammation, chondrocyte hypertrophy, and meniscal mineralization are mitigated through oligofructose, a non-digestible prebiotic fiber that facilitates the expansion of beneficial Bifidobacteria and improves insulin resistance (49). In addition, studies have investigated the therapeutic effects of OA by controlling gut microbiota through the administration of Bifidobacterium longum or prebiotic fiber supplementation (50,51). Deletion of IL-1Ra changes the composition of intestinal microbial and decreases the diversity depending on toll-like receptor 4, and the production of IL-17 is significantly increased in the lamina propria lymphocytes of such mice; this indicates that IL-1Ra may regulate the diversity and composition of intestinal microbiota (52).…”

Section: Discussionmentioning

confidence: 99%

Interleukin-1-Interleukin-17 Signaling Axis Induces Cartilage Destruction and Promotes Experimental Osteoarthritis

Na¹,

Park²,

Cho³

et al. 2020

Front. Immunol.

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Osteoarthritis (OA), which is the most common degenerative joint disorder, has been considered a non-inflammatory disease with abnormal mechanics. Interleukin (IL)-17 is a pleiotropic cytokine involved in inflammatory diseases and their production is driven by the cytokine including IL-1 and IL-23. However, little is known about the mechanism of IL-17 in the development of OA. Here, we investigated the role of IL-17 in the pathogenesis of OA using monosodium iodoacetate (MIA)-injected IL-17 and IL-1 receptor antagonist (IL-1Ra) double-deficient mice. In MIA-injected IL-1Ra KO mice, nociceptive properties, degree of cartilage damage, and the level of inflammatory factors in articular cartilage were increased compared to MIA-injected wild-type mice. Interestingly, the intestinal architecture was impaired in IL-1Ra KO mice compared to wild-type mice and the damage was further exacerbated by MIA injection. Deficiency of IL-17 reduced nociceptive properties and cartilage destruction, as well as inflammationrelated factors in MIA-injected IL-1Ra KO mice compared to MIA-injected wild-type mice. Furthermore, IL-17-treated chondrocytes from OA patients showed enhanced expression of catabolic factors that are involved in the destruction of cartilage in OA. IL-17 accelerates the destruction of cartilage and small intestine via regulation of several inflammatory mediators in an OA murine model. These results suggest that IL-17 plays a critical role in the development of OA.

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“…Germ-free mice were shown to be more resistant to development of osteoarthritis after joint injury [168], suggesting the potent role of gut microbiota in osteoarthritis pathogenesis. Interestingly, treatment with lyophilized inactivated culture of Bifidobacterium longum protected cartilage structure lesions and decreased type II collagen degradation in a spontaneous model of osteoarthritis [169]. In addition, the prebiotic fiber supplementation displayed the protective effect on osteoarthritis development in the rat model of obesity [170].…”

Section: The Role Of Microbiome In Septic Arthritis and Sepsismentioning

confidence: 99%

Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis

et al. 2021

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Staphylococcus aureus (S. aureus) infections are a major healthcare challenge and new treatment alternatives are needed. S. aureus septic arthritis, a debilitating joint disease, causes permanent joint dysfunction in almost 50% of the patients. S. aureus bacteremia is associated with higher mortalities than bacteremia caused by most other microbes and can develop to severe sepsis and death. The key to new therapies is understanding the interplay between bacterial virulence factors and host immune response, which decides the disease outcome. S. aureus produces numerous virulence factors that facilitate bacterial dissemination, invasion into joint cavity, and cause septic arthritis. Monocytes, activated by several components of S. aureus such as lipoproteins, are responsible for bone destructions. In S. aureus sepsis, cytokine storm induced by S. aureus components leads to the hyperinflammatory status, DIC, multiple organ failure, and later death. The immune suppressive therapies at the very early time point might be protective. However, the timing of treatment is crucial, as late treatment may aggravate the immune paralysis and lead to uncontrolled infection and death.

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Protective Actions of Oral Administration of Bifidobacterium longum CBi0703 in Spontaneous Osteoarthritis in Dunkin Hartley Guinea Pig Model

Cited by 33 publications

References 39 publications

The role of gut microbiota in bone homeostasis

The role of gut microbiota in bone homeostasis

Interleukin-1-Interleukin-17 Signaling Axis Induces Cartilage Destruction and Promotes Experimental Osteoarthritis

Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis

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