Protective actions of vitamin D, anandamide and melatonin during vascular inflammation: Epigenetic mechanisms involved

Giménez, Virna Margarita Martín; Chuffa, Luiz Gustavo de Almeida; Simão, Vinícius Augusto; Reíter, Russel J.; Manucha, Walter

doi:10.1016/j.lfs.2021.120191

Cited by 10 publications

(5 citation statements)

References 162 publications

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“…Moreover, in obese people, hyperleptidemia is usually observed. This disorder provokes vascular inflammation [ 29 ]. The 1,25(OH)2D3 pretreatment of cultured human umbilical vein-derived endothelial cells exposed to high concentrations of leptin with 1,25(OH)2D3 prevented the rise in the expression of vascular pro-inflammatory mediators caused by leptin, including CCL2, VCAM-1, and transforming growth factor β (TGF-β) [ 30 ].…”

Section: Pleiotropic Effects Of Vitamin D In Inflammatory-based Diseasesmentioning

confidence: 99%

“…Epigenetics might explain the interplay between environment and genetics in the development, progression, pathogenicity of disease, and the response to treatments. Epigenetics changes occur in the following ways: DNA methylation, which generates methyl cytosine in CpG dinucleotides sites leading to transcriptional silencing, histone modifications, chromatin remodeling, and noncoding RNAs regulation [ 29 ]. RNAs are untranslated transcripts that play an important role in the post-transcriptional regulation of gene expression and can be classified into short, mid, and long based on their length.…”

Section: Genetic and Epigenetic Regulation Of Inflammation By Vitamin Dmentioning

confidence: 99%

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Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases

et al. 2023

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Vitamin D (vit D) is widely known for its role in calcium metabolism and its importance for the bone system. However, various studies have revealed a myriad of extra-skeletal functions, including cell differentiation and proliferation, antibacterial, antioxidant, immunomodulatory, and anti-inflammatory properties in various cells and tissues. Vit D mediates its function via regulation of gene expression by binding to its receptor (VDR) which is expressed in almost all cells within the body. This review summarizes the pleiotropic effects of vit D, emphasizing its anti-inflammatory effect on different organ systems. It also provides a comprehensive overview of the genetic and epigenetic effects of vit D and VDR on the expression of genes pertaining to immunity and anti-inflammation. We speculate that in the context of inflammation, vit D and its receptor VDR might fulfill their roles as gene regulators through not only direct gene regulation but also through epigenetic mechanisms.

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Section: Pleiotropic Effects Of Vitamin D In Inflammatory-based Diseasesmentioning

confidence: 99%

Section: Genetic and Epigenetic Regulation Of Inflammation By Vitamin Dmentioning

confidence: 99%

Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases

et al. 2023

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“…Vitamin D deficiency and insufficiency is more prevalent in African Americans, smokers, obese individuals, and people with chronic diseases such as diabetes, hypertension, and various gastroenterological disorders [64] , [65] , [66] , [67] . In COVID-19, the high-risk patients with the greatest complications and death rates are also those with a poor vitamin D status [13] , [16] , [17] , [18] , [19] , [68] , [69] , [70] .…”

Section: Vitamin D and Covid-19mentioning

confidence: 99%

COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent

et al. 2022

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“…Recently, the antioxidant vitamin D has been intensely studied, especially due to the inflammatory mechanisms that are induced upon infection by the new SARS-CoV-2 coronavirus [ 234 , 235 ]. Recent studies have shown that decreased plasma concentrations for vitamin D are associated with an increase in pro-inflammatory and pro-oxidative factors, such as TNF-α, IL-6, fibrinogen, and C reactive protein [ 236 ].…”

Section: Perioperative Antioxidant Therapymentioning

confidence: 99%

The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy

Ritiu

Rogobete

Săndesc

et al. 2022

Cells

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Worldwide, the prevalence of surgery under general anesthesia has significantly increased, both because of modern anesthetic and pain-control techniques and because of better diagnosis and the increased complexity of surgical techniques. Apart from developing new concepts in the surgical field, researchers and clinicians are now working on minimizing the impact of surgical trauma and offering minimal invasive procedures due to the recent discoveries in the field of cellular and molecular mechanisms that have revealed a systemic inflammatory and pro-oxidative impact not only in the perioperative period but also in the long term, contributing to more difficult recovery, increased morbidity and mortality, and a negative financial impact. Detailed molecular and cellular analysis has shown an overproduction of inflammatory and pro-oxidative species, responsible for augmenting the systemic inflammatory status and making postoperative recovery more difficult. Moreover, there are a series of changes in certain epigenetic structures, the most important being the microRNAs. This review describes the most important molecular and cellular mechanisms that impact the surgical patient undergoing general anesthesia, and it presents a series of antioxidant therapies that can reduce systemic inflammation.

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Protective actions of vitamin D, anandamide and melatonin during vascular inflammation: Epigenetic mechanisms involved

Cited by 10 publications

References 162 publications

Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases

Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases

COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent

The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy

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