Protective activity of components of an edible plant, Mallotus japonicus, against oxidative modification of proteins and lipids

Tabata, Hiromasa; Katšube, Takao; Moriya, Koko; Utsumi, Toshihiko; Yamasaki, Yukikazu

doi:10.1016/j.foodchem.2009.05.033

Cited by 15 publications

(3 citation statements)

References 24 publications

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“…repandus stems exhibited the greatest superoxide-scavenging activity . On the other hand, Tabata and co-workers demonstrated the antioxidant effects of mallotinic acid, which is a strong free-radical scavenger and can inhibit ROS-mediated protein degradation of bovine serum albumin . Similarly, furosin exerts protective effects which reduce glutamate-induced oxidative stress and inhibit apoptotic cell death .…”

Section: Discussionmentioning

confidence: 99%

“…41 On the other hand, Tabata and co-workers demonstrated the antioxidant effects of mallotinic acid, which is a strong free-radical scavenger and can inhibit ROS-mediated protein degradation of bovine serum albumin. 42 Similarly, furosin exerts protective effects which reduce glutamate-induced oxidative stress and inhibit apoptotic cell death. 43 Sunitha et al demonstrated the hepatoprotective effect of lupeol against cadmium-induced toxicity in rats.…”

Section: D-mentioning

confidence: 99%

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Hepatoprotective and Antioxidant Capacity of Mallotus repandus Ethyl Acetate Stem Extract against d-Galactosamine-Induced Hepatotoxicity in Rats

et al. 2020

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Mallotus repandus (M. repandus) is traditionally used to treat muscle pain, itching, fever, rheumatic arthritis, and a variety of liver disorders. The aim of the present work was to evaluate the hepatoprotective activity and the antioxidant potential of the ethyl acetate stem extract of M. repandus (ESMR) against d-galactosamine (d-GalN)-induced hepatopathy, along with a possible mechanism of action in rats. In vivo hepatoprotective activity of ESMR was examined using d-galactosamine (d-GalN)-induced hepatotoxicity in Sprague–Dawley rats. For this purpose, levels of serum diagnostic markers, activity of hepatic antioxidant enzymes, and liver histo-architecture were employed to assess the protective efficacy of ESMR. Furthermore, the total phenolic, flavonoid, and tannin contents were quantitated, and the antioxidant capacity of the extract was evaluated using different methods such as 2,2′-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO), hydrogen peroxide (H2O2), and hydroxyl radical (OH•) scavenging assays. Intraperitoneal d-GalN injection triggered hepatotoxicity, as shown by the noticeable increase in the serum hepatic marker enzymes, bilirubin content, γ-glutamyl transferase (GGT), total cholesterol (TC), triglycerides (TGs), and malondialdehyde (MDA), whereas glutathione, superoxide dismutase, and catalase levels were significantly lower compared with that of the control. Pretreatment with ESMR reduced the hepatic enzyme levels along with bilirubin, GGT, and MDA compared to the d-GalN-intoxicated group. These results were supported by histopathological studies, where d-galactosamine caused coagulative necrosis, hemorrhage, and inflammation. However, pretreatment with ESMR ameliorated the histo-architectural changes and brought them back to normal. Results also revealed that the total polyphenolic, flavonoid, and tannin content, and total antioxidant capacity of ESMR were 136.30 ± 0.78 mg GAE/g mg, 38.72 ± 0.85 mg QE/g, 75.88 ± 0.54 mg TAE/g, and 123.16 ± 0.24 mg AAE/g, respectively. In addition, ESMR inhibited free radicals with IC50 values of 94.47 ± 0.51, 127.33 ± 0.36, 164.12 ± 0.45, and 254.14 ± 0.35 μg/mL in DPPH, NO, H2O2, and OH• free radical scavenging assays, respectively. These findings highlight the protective role of ESMR against hepatic injury induced by d-GalN, which may be attributed to its higher antioxidant properties, thereby scientifically justifying its traditional use.

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Section: Discussionmentioning

confidence: 99%

Section: D-mentioning

confidence: 99%

Hepatoprotective and Antioxidant Capacity of Mallotus repandus Ethyl Acetate Stem Extract against d-Galactosamine-Induced Hepatotoxicity in Rats

et al. 2020

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“…We were successful in determining the precise accumulation pattern of a number of different classes of specialised metabolites in M. japonicus by employing a method that is known as untargeted metabolomics. The expression data from the collected transcripts as well as the intensities of the MS2 verified metabolites were used in a WCNA-based network analysis that was carried out [17][18][19][20]. The goal of this research was to find modules, which are groups of genes or metabolites that have certain properties in common with one another.…”

Section: Introductionmentioning

confidence: 99%

In-vitro Anti-Ulcer Activities of Mallotus Japonicus

Koka¹,

Gayakwad²,

Shraddha³

et al. 2022

J. Res. Appl. Sci. Biotechnol.

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Objectives: This study's objective was to investigate whether or not a methanolic extract of Mallotus japonicas could decrease H+-K+ ATPase activity and neutralise acid. Materials and Methods: We assessed the total phenolic and flavonoid contents of the sample while it was exposed to varying amounts of standard esmoprazole and methanol extract. Results: The proton pump inhibitory activity of the extract from stomach mucosal homogenate was found to be significant (*P<0.05) and on par with the standard. Conclusions: Based on these findings, it may be concluded that the proton pump can be effectively blocked by the methanolic extract.

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The leaf extract of Mallotus japonicus and its major active constituent, rutin, suppressed on melanin production in murine B16F1 melanoma

Taira

Tsuchida

Uehara

et al. 2015

Asian Pacific Journal of Tropical Biomedicine

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Protective activity of components of an edible plant, Mallotus japonicus, against oxidative modification of proteins and lipids

Cited by 15 publications

References 24 publications

Hepatoprotective and Antioxidant Capacity of Mallotus repandus Ethyl Acetate Stem Extract against d-Galactosamine-Induced Hepatotoxicity in Rats

Hepatoprotective and Antioxidant Capacity of Mallotus repandus Ethyl Acetate Stem Extract against d-Galactosamine-Induced Hepatotoxicity in Rats

In-vitro Anti-Ulcer Activities of Mallotus Japonicus

The leaf extract of Mallotus japonicus and its major active constituent, rutin, suppressed on melanin production in murine B16F1 melanoma

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