Protective Activity of Silipide on Liver Damage in Rodents

Abstract

ABSTRACT-The activity of silipide, a silybin-phosphatidylcholine complex (IdB 1016), was tested in different models of liver damage in rodents. After oral administration, silipide exhibited a significant and dose-related protective effect against the hepatotoxicity induced by CC14, praseodymium, ethanol and galactosamine. The ED50 values for inhibition of the rise in ASAT and ALAT levels caused by CC14 and praseodymium and for antagonism of the increase in liver triglycerides caused by ethanol ranged from 93 to 156 mg/kg (as silybin). At a dose of 400 mg/kg (as silybin), silipide was also active in protecting against paracetamol-induced hepatotoxicity. Silybin and phosphatidylcholine at doses equivalent to those contained in the active doses of silipide failed to show any significant protective activity in these models. The liver protective effect of silipide is probably related to its antioxidant activ ities and to a stimulating effect on the hepatic synthesis of RNA and proteins.

The Gallic Acid–Phospholipid Complex Improved the Antioxidant Potential of Gallic Acid by Enhancing Its Bioavailability

“…Our previous works on hesperitin (21), quercetin (22), and curcumin (35) show that the hepatoprotective activity Values are means ± SD of these phytomolecules was improved by the phospholipid complexation in a dose-dependent manner. Silipide (a silybin-phospholipid complex) was found to improve the hepatoprotection of silybin both in human and animal models (36,37). In the present study, GA-HSPC complex showed better efficacy in comparison with pure molecule-treated group as well as group receiving physical mixture of GA and HSPC.…”

Mitigative effects of Moringa oleifera against liver injury induced by artesunate-amodiaquine antimalarial combination in wistar rats

“…Given that silybin is lipidincompatible, the combination with phosphatidylcholine facilitates passage of the flavonoid through biological membranes [7]. Some workers have reported on the protective effect of Siliphos ® against carbon tetrachloride, acetaminophen, alcohol and mushroom poisoning [7,[34][35][36].…”

Exposure, Metabolism, and Toxicity of Rare Earths and Related Compounds

“…The first three RE decreased RNA polymerase II activity while the latter three RE increased the activity; only Pr and Nd nitrates decreased RNA polymerase I activity while the other four did not change the RNA polymerase I activity. Otherwise, the biochemical changes are consistent among RE; those biochemical changes are increase in triglyceride in the liver (105,110,113,117) and increases in leakage of hepatic enzymes into blood (46,105,(111)(112)(113)(114)(115)(116). RE-induced hepatic injury seems to reduce P450 content and P450-related enzyme activities in rat (113) and mouse (109,119); however, the decreases in P450 activities (coumarin 7-hydroxylase and 7-ethoxyresorufin O-deethylase) at 3 to 4 days after iv injection of CeCI3 were preceded by increases in these enzyme activities at 1 to 2 days postinjection in DBA/2 mice (109,119).…”