Background: Hypoglycemia is a well-recognized complication between type I diabetes patients, and it is the most common diabetes-related emergency. It is an unavoidable diabetic complication as it raises mortality and morbidity rates in those with DM. Thus, better outcomes, shorter hospital stays, and fewer complications are achieved when hypoglycemic patients get coordinated nursing care. Aim: Assess the effects of nursing-directed protocol on the occurrence of hypoglycemic episodes among patients at Medical Intensive Care Unit (ICU). Design: Quasi-experimental research design. Setting: This study was conducted at the Medical Intensive Care Unit at Tanta Main University Hospital. Subjects: Purposive sampling of 60 adult patients with hypoglycemia who meet all inclusion criteria, were split into 2 equal groups, with 30 individuals in each group. Tools: 3 different tools were employed to collect the data. Tool (I): Patients structured assessment tool; socio-demographic data of the patients, patient`s clinical data. Tool (II): Blood glucose measurements flow sheet tool; capillary blood glucose measurements, glycemic penalty index tool. Tool (III): Monitoring hypoglycemic manifestation and its complications among critically ill patients. Result: The main results showed that the study group had significantly improved in terms of vital signs, consciousness, and blood glucose readings. Statically significant difference was observed related to hypoglycemic manifestation and complication among the control and study group with P<0.05. Conclusion: The nursing-directed protocol had positive effect on decreasing hypoglycemic episode by improving blood glucose level, reducing hypoglycemic manifestations and complications. Recommendation: Our findings should be repeated with a broader probability sample and in a numerous region to ensure that the findings are generally applicable.